Results 41 to 50 of about 101,128 (273)

Exocomets size distribution in the $$\beta$$ β Pictoris planetary system

Scientific Reports, 2022
The star $$\beta$$ β  Pictoris harbors a young planetary system of about 20 million years old, which is characterized by the presence of a gaseous and dusty debris disk, at least two massive planets and many minor bodies.
Alain Lecavelier des Etangs, Lucie Cros, Guillaume Hébrard, Eder Martioli, Marc Duquesnoy, Matthew A. Kenworthy, Flavien Kiefer, Sylvestre Lacour, Anne-Marie Lagrange, Nadège Meunier, Alfred Vidal-Madjar   +10 more
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Effect of age on the presence of comet tails at high altitude

, 2019
Extravascular lung water (EVLW) increases in healthy adults upon exposure to high altitude, likely due to increased pulmonary vascular resistance (PVR).
Coffman, KE, Johnson, BD, Wheatley, CM, Stewart, GM, Carlson, AR   +4 more
core   +1 more source

Progress towards COMET Phase-I [PDF]

, 2015
The COMET experiment is designed to search for flavour violation in the charged lepton sector, via the coherent neutrinoless process +A e+A, which can probe a wide variety of BSM physics. Using the new high-power proton beam at J-PARC, the sensitivity of
COMET Collaboration, ., Litchfield, R. Phillip   +1 more
core   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Concerning a new theory of Type I comet tails [PDF]

, 1965
Enhanced density plasma confinement hypothesis for formation of Type I comet tails following interaction with solar ...
Ness, N. F., Donn, B. D.
core  

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Hubble Space Telescope Observations of the Interstellar Interloper 3I/ATLAS

The Astrophysical Journal Letters
We present high-angular-resolution observations of the third known interstellar interloper, 3I/ATLAS, from the Hubble Space Telescope. The object is clearly active at 3.8 au preperihelion, showing dust emitted from the hot, Sun-facing side of the nucleus
David Jewitt, Man-To Hui, Max Mutchler, Yoonyoung Kim, Jessica Agarwal   +4 more
doaj   +1 more source

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction. [PDF]

PLoS ONE, 2013
The Shigella flexneri IcsA (VirG) protein is a polarly distributed outer membrane protein that is a fundamental virulence factor which interacts with neural Wiskott-Aldrich syndrome protein (N-WASP). The activated N-WASP then activates the Arp2/3 complex
Min Yan Teh, Renato Morona
doaj   +1 more source

Baculovirus-induced actin comet tails [PDF]

, 2011
Diese Arbeit beschreibt meine Forschung der letzten eineinhalb Jahre in der Arbeitsgruppe von Prof. J. Victor Small am Institut für Molekulare Biotechnologie (IMBA) der Österreichischen Akademie der Wissenschaften.
Müller, Jan
core