Results 41 to 50 of about 4,657 (224)
Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop
Advanced Science, EarlyView.To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang +9 morewiley +1 more sourceDielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells
Advanced Intelligent Systems, EarlyView.Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard +6 morewiley +1 more sourceLinear Viscoelastic Behavior of n‐Alkane Diluted Polyethylene Melts: Sorption, Desorption, and Oscillatory Rheometry
Journal of Applied Polymer Science, EarlyView.This study systematically maps polyolefin dilution dynamics using a homologous series of n‐alkanes. Integrating gravimetric sorption, subsequent controlled desorption, and oscillatory rheometry establishes a precise framework to analyze reduction in viscosity at least for polymer diluent mixtures with polymer concentration > 35% and diluent ...Ernst Georg Viehböck, Georg Gschwendner, Dario Pindrić, Gunnar Spiegel, Alexander Hammer, Christian Paulik, Gerald Berger‐Weber +6 morewiley +1 more sourceNSF-DOE Vera C. Rubin Observatory Observations of Interstellar Comet 3I/ATLAS (C/2025 N1)
The Astrophysical Journal LettersWe report on the observation and measurement of astrometry, photometry, morphology, and activity of the interstellar object 3I/ATLAS, also designated C/2025 N1 (ATLAS) with the NSF-DOE Vera C. Rubin Observatory.Colin Orion Chandler, Pedro H. Bernardinelli, Mario Jurić, Devanshi Singh, Henry H. Hsieh, Ian Sullivan, R. Lynne Jones, Jacob A. Kurlander, Dmitrii Vavilov, Siegfried Eggl, Matthew Holman, Federica Spoto, Megan E. Schwamb, Lauren A. MacArthur, Rahil Makadia, Marco Micheli, Aren Heinze, Eric J. Christensen, Wilson Beebe, Aaron Roodman, Kian-Tat Lim, Tim Jenness, James Bosch, Brianna M. Smart, Eric Bellm, Sean MacBride, Meredith L. Rawls, Sarah Greenstreet, Colin Slater, Željko Ivezić, Robert D. Blum, Andrew Connolly, Gregory Daues, Michelle Gower, J. Bryce Kalmbach, Michele T. Bannister, Luke Dones, Rosemary C. Dorsey, Davide Farnocchia, Wesley C. Fraser, John C. Forbes, Cesar Fuentes, Carrie E. Holt, Laura Inno, Geraint H. Jones, Matthew M. Knight, Chris J. Lintott, Tim Lister, Robert Lupton, Mark Jesus M. Magbanua, Renu Malhotra, Beatrice E. A. Mueller, Joseph Murtagh, Nitya Pandey, William T. Reach, Nalin H. Samarasinha, Darryl Z. Seligman, Colin Snodgrass, Michael Solontoi, Gyula M. Szabó, Peter Vereš, Ellie White, Maria Womack, Leslie A. Young, Russ Allbery, Shreya Anand, Roberto Armellin, Éric Aubourg, Chrysa Avdellidou, Farrukh Azfar, James Bauer, Keith Bechtol, Valerie Becker, Matthew Belyakov, Susan D. Benecchi, Ivano Bertini, Dennis Bodewits, Patricia Boeshaar, Bryce T. Bolin, Maitrayee Bose, Alexandre Boucaud, Rodrigo C. Boufleur, Dominique Boutigny, Andrew Bradshaw, Felipe Braga-Ribas, Johan Bregeon, Laura E. Buchanan, Daniel Calabrese, J. I. B. Camargo, Neven Caplar, Jeffrey L. Carlin, Benoit Carry, Juan Pablo Carvajal, Ross Ceballo, Hsin-Fang Chiang, Yumi Choi, Céline Combet, Luiz da Costa, Preeti Cowan, John Franklin Crenshaw, Steve Croft, Matija Ćuk, Philip N. Daly, Filippo D’Ammando, Felipe Daruich, Guillaume Daubard, James R. A. Davenport, Tansu Daylan, Jennifer Delgado, Hadrien A. R. Devillepoix, Peter E. Doherty, Abbie Donaldson, Holger Drass, Stephanie J. H. Deppe, Gregory P. Dubois-Felsmann, Peter S. Ferguson, Frossie Economou, Marielle R. Eduardo, Ioana Sotuela Elorriaga, Anthony Englert, Edward Karavakis, Kevin Fanning, Maxwell K. Frissell, Grigori Fedorets, Maryann Benny Fernandes, Agnès Ferté, Merlin Fisher-Levine, Mark L Freytag, Marco Fulle, Poshak Gandhi, John Gates, David W. Gerdes, Alex R. Gibbs, A. Fraser Gillan, Massimiliano Giordano Orsini, T. Glanzman, Iain Goodenow, Altair Ramos Gomes-Júnior, Miranda R. Gorsuch, Mikael Granvik, Wen Guan, Leanne P. Guy, Mark Hammergren, Andrew Hanushevsky, Fabio Hernandez, Ǎdis Herrold, Daniel Hestroffer, Joshua Hoblitt, Guillem Megias Homar, Matthew J. Hopkins, Simone Ieva, Patrick Ingraham, David H. Irving, Buell T. Jannuzi, M. James Jee, David Jimenez, Claire Juramy, Steven M. Kahn, Yijung Kang, Arun Kannawadi, JJ Kavelaars, Michael S. P. Kelley, Kshitija Kelkar, Lee S. Kelvin, Ivan Kotov, Alec Koumjian, Gábor Kovács, K. Simon Krughoff, Agnieszka Kryszczyńska, Petr Kubánek, Craig Lage, Travis J. Lange, Pierre-François Léget, Laurent Le Guillou, Benjamin Levine, W. Garrett Levine, Zhuofu (Chester) Li, Shuang Liang, Javier Licandro, Hsing Wen Lin, Carey Lisse, Nate B. Lust, Ryan R. Lyttle, Ashish A. Mahabal, Max Mahlke, Gabriele Mainetti, Rachel Mandelbaum, Steven J. Margheim, Giuliano Margoti, Phil Marshall, Andrés A. Plazas Malagón, Dušan Marčeta, Mario D. Melita, Felipe Menanteau, Joshua Meyers, Dave Mills, Marc Moniez, C.A.L. Morales Marín, Naomi Morato, Surhud More, Christopher B. Morrison, Kris Mortensen, Youssef Moulane, Karlo Mrakovčić, Fritz Mueller, Marco A. Muñoz-Gutiérrez, Homer Neal, F. M. Newcomer, Erfan Nourbakhsh, Paul O’Connor, Drew Oldag, William J. Oldroyd, William O’Mullane, Cyrielle Opitom, Dagmara Oszkiewicz, Gary L. Page, Jack Patterson, Maria T Patterson, Matthew J. Payne, Eske M. Pedersen, Julien Peloton, Chrystian Luciano Pereira, John R. Peterson, Stephen R. Pietrowicz, Edyta Podlewska-Gaca, Rebekah Polen, Daniel Polin, Hannah Mary Margaret Pollek, Yongqiang Qiu, Bruno Quint, Markus Rabus, Darin Ragozzine, Jayadev Rajagopal, Arianna Ranabhat, Kevin Reil, Tiago Ribeiro, Malena Rice, Stephen T. Ridgway, Steven M. Ritz, Andrew S. Rivkin, James E. Robinson, Agata Rożek, Eli Rykoff, Luis E. Salazar Manzano, Andrei Salnikov, Bruno O. Sánchez, David Sanmartim, Gal Sarid, Charles A. Schambeau, Rafe H. Schindler, Samuel J. Schmidt, German Schumacher, Theo Schutt, Daniel Scolnic, Robert Seaman, Jacques Sebag, Nima Sedaghat, Jacqueline Seron, Richard A. Shaw, Alysha Shugart, Jonathan Sick, Jaladh Singhal, Amir Siraj, Michael C. Sitarz, Adam Snyder, Shahram Sobhani, Christine Soldahl, Dallin Spencer, Brian Stalder, Steven Stetzler, Alan Strauss, Christopher W. Stubbs, Krzysztof L. Suberlak, John D. Swinbank, László Szigeti, Dan S. Taranu, Michael Tauraso, John Gregg Thayer, Sandrine Thomas, Adam Thornton, Luca Tonietti, Laura Toribio San Cipriano, David E. Trilling, Chadwick A. Trujillo, Te-Wei Tsai, Douglas L. Tucker, Max Turri, Tony Tyson, Elana K. Urbach, Wouter van Reeven, Antonia Sierra Villarreal, Stelios Voutsinas, Christopher W. Walter, Yuankun (David) Wang, Charlotte Ward, Michael Warner, Maxine West, Emerson Whittaker, Ian Wong, W. M. Wood-Vasey, Bin Yang, Quanzhi Ye, Peter Yoachim, R. Zanmar Sanchez, Jinshuo Zhang, Conghao Zhou +305 moredoaj +1 more sourceSkeletal pathologies in extant crocodilians as a window into the paleopathology of fossil archosaurs
The Anatomical Record, EarlyView.Abstract
Crocodilians, together with birds, are the only extant relatives to many extinct archosaur groups, making them highly important for interpreting paleopathological conditions in a phylogenetic disease bracketing model. Despite this, comprehensive data on osteopathologies in crocodilians remain scarce.Alexis Cornille, Kyla Beguesse, Ewan Wolff, Clemens Zinner, Patrick Asbach, François Clarac, Florian Witzmann +6 morewiley +1 more source
