Results 41 to 50 of about 38,833 (299)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Les Cahiers de Framespa, 2017 Visitors to the Lava Beds National Monument discover a site where the National Park Service has to orchestrate features of geological, historical, and environmental interest.
Wendy Harding, Jacky Martin
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tabularia, 2022 Examination of Avranches, Bibl. patrimoniale, ms 214 shows that it contains the Chapter Book used for memorialization of the dead in the office of Chapter from c. 1212 to c.
Katharine S. B. Keats-Rohan
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Kronos, 2010 This article examines recent contestations over the commemoration of King Makhado of the Venda at the town of Louis Trichardt in Limpopo Province, South Africa.
Mahunele Thotse
doaj
Who fought for national freedom? On the significance of the Great War in interwar Lithuania
Acta Baltico-Slavica, 2018 Who fought for national freedom? On the significance of the Great War in interwar Lithuania Even though the First World War was caused by tension in the east of Europe, not so long ago, quite a number of historians, as if repeating the words of Winston
Vasilijus Safronovas
doaj +1 more source
Remembrance of Things Past: Historical Commemoration in an Educational Setting [PDF]
, 2017 This chapter explores how an Australian day and boarding college for male students between the ages of 10 and 17 partnered with a regional university to explore the centenary commemoration of World War 1 through an Australian Government Arts and Culture ...
Baguley, Margaret +3 more
core +1 more source