Results 51 to 60 of about 112,605 (299)

‘Forebears’, ‘saints’ and ‘martyrs’: the politics of commemoration in Bulgaria in the 1880s and 1890s [PDF]

open access: yes, 2008
Book description: The relationship between states, societies, and individuals in Central and Eastern Europe has been characterised by periods of change and redefinition.
Detchev, S.
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Contesting names and statues: battles over the Louis Trichardt/Makhado 'city-text' in Limpopo Province, South Africa

open access: yesKronos, 2010
This article examines recent contestations over the commemoration of King Makhado of the Venda at the town of Louis Trichardt in Limpopo Province, South Africa.
Mahunele Thotse
doaj  

Adolfo Sánchez Vázquez i les “memorias rotas” dels exiliats espanyols de 1939 a Mèxic. Un concepte seminal per a la sociologia del passat

open access: yesDigithum, 2017
Amb motiu de la commemoració del centenari del naixement d’Adolfo Sánchez Vázquez el 2015, es van celebrar a Mèxic una sèrie d’homenatges entorn de la seva figura i del seu llegat.
Laura Angélica Moya López
doaj   +1 more source

From Center to periphery and vice versa: The politics of toponyms in the transitional capital [PDF]

open access: yesGlasnik Etnografskog Instituta SANU, 2008
This paper discusses the politics of street names in Belgrade since the beginning of 1990s until today. Given the central place of the capital city in the symbolic geography of the nation, subsequent cultural influences of the capitals' 'city text ...
Radović Srđan
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

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