Results 51 to 60 of about 120,456 (335)

‘Forebears’, ‘saints’ and ‘martyrs’: the politics of commemoration in Bulgaria in the 1880s and 1890s [PDF]

open access: yes, 2008
Book description: The relationship between states, societies, and individuals in Central and Eastern Europe has been characterised by periods of change and redefinition.
Detchev, S.
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Contesting names and statues: battles over the Louis Trichardt/Makhado 'city-text' in Limpopo Province, South Africa

open access: yesKronos, 2010
This article examines recent contestations over the commemoration of King Makhado of the Venda at the town of Louis Trichardt in Limpopo Province, South Africa.
Mahunele Thotse
doaj  

Go East, Old Man: The Ritual Spaces of SS Veterans' Memory Work

open access: yesCulture Unbound: Journal of Current Cultural Research, 2014
This article uses social-movement analysis to understand the rituals, memory-work and spatialties of Waffen-SS veterans and their sympathizers. Most social-movement analysis focuses on left-wing protesters; our concern is with the marginalized counter ...
Steffen Werther, Madeleine Hurd
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

DIMITRIE GUSTI ȘI BREXIT-UL. DE UNDE TREBUIE SĂ ÎNCEAPĂ O DISCUȚIE DESPRE EUROPA FEDERALĂ [PDF]

open access: yesRevista de Știinţe Politice şi Relaţii Internaţionale, 2020
This year we celebrate the 140th anniversary of the birth of the sociologist Dimitrie Gusti. The best way to pay homage to him is to prove his overwhelming vitality of his interrogations and diagnoses.
DAN DUNGACIU
doaj  

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