Results 111 to 120 of about 2,393,076 (337)
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Representation Learning for cold-start recommendation
, 2014 A standard approach to Collaborative Filtering (CF), i.e. prediction of user ratings on items, relies on Matrix Factorization techniques. Representations for both users and items are computed from the observed ratings and used for prediction ...
Artieres, Thierry +2 more
core +1 more source
Intra-annual genotypic patterns of growth and water use of irrigated rice in the Sahel [PDF]
, 2011 With an increasing world population, the demand for rice as one of the most important staple crops is growing. Rice production can be increased either by intensification of existing or by exploitation of new and less favourable land resources.
Asch, Folkard +4 more
core
FEBS Open Bio, EarlyView.NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi +6 more
wiley +1 more source
MedUNABIntroduction. Eosinophils modulate innate and adaptive immunity. Their elevation may be associated with changes in neutrophil concentrations during acute upper respiratory tract infections.
Guevara-Tirado, Alberto
doaj +1 more source
Power enhancement of heat engines via correlated thermalization in multilevel systems
, 2014 We analyze a heat machine based on a periodically-driven quantum system permanently coupled to hot and cold baths. It is shown that the maximal power output of a degenerate $V$-type three-level heat engine is that generated by two independent two-level ...
Brumer, Paul +3 more
core +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
Tear Lactoferrin and Lysozyme as Clinically Relevant Biomarkers of Mucosal Immune Competence
Frontiers in Immunology, 2019 Tears have attracted interest as a minimally-invasive biological fluid from which to assess biomarkers. Lactoferrin (Lf) and lysozyme (Lys) are abundant in the tear fluid and have antimicrobial properties.
Helen G. Hanstock +3 more
doaj +1 more source
Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley +1 more source
Proper phase imprinting method for a dark soliton excitation in a superfluid Fermi mixture
, 2014 It is common knowledge that a dark soliton can be excited in an ultra-cold atomic gas by means of the phase imprinting method. We show that, for a superfluid fermionic mixture, the standard phase imprinting procedure applied to both components fails to ...
Delande, Dominique, Sacha, Krzysztof
core +1 more source