Results 61 to 70 of about 6,106,849 (291)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2023 Number of hospital admissions (A) and emergency department (ED) visits associated with the common cold coronavirus. (PDF)
Steven Habbous (7408880) +4 more
core +1 more source
Biomedicine Hub, 2021 Background/Aims: Nasal saline irrigation is a common procedure to relieve nasal symptoms in upper respiratory tract diseases. There is no consensus on the recommended nasal saline delivery devices.
Patorn Piromchai +2 more
doaj +1 more source
Antihistamines for the common cold [PDF]
Cochrane Database of Systematic Reviews, 2003 Although antihistamines are prescribed in large quantities for the common cold, there is little evidence to whether these drugs are effective.To assess in patients with a common cold the effects of antihistamines in alleviating nasal symptoms, or in shortening of illness duration.We searched the Cochrane Acute Respiratory Infections Group Specialized ...
A I M, Sutter +3 more
openaire +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Behavioral Sciences, 2012 Previous research has shown that both experimentally induced upper respiratory tract illnesses (URTIs) and naturally occurring URTIs influence mood and performance.
Andrew P. Smith
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Low Fatigue Response of Crest-Fixed Cold-Formed Steel Drape Curved Roof Claddings [PDF]
, 2018 Cold-formed steel roof claddings are subjected to significant suction/uplift pressures during high wind events. In New Zealand, the strong prevailing winds makes this a common occurrence. Suction pressures are generated by the turbulence of the wind flow
Lim, J. B. +9 more
core
Cover photos for Common Thread Podcast 2018
, 2018 Cover Photos for the Common Thread PodcastBoston University Howard Thurman Center for Common ...
Boston University Howard Thurman Center for Common Ground
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source