Results 71 to 80 of about 6,040,073 (242)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Information Commons: a public policy report [PDF]
, 2004 This report describes the history of the information commons, presents examples of online commons that provide new ways to store and deliver information, and concludes with policy recommendations.
Kranich, Nancy C.
core
Proceedings of the Edinburgh Mathematical Society, 1966 A well-known theorem in group theory [(8), p. 11, Satz 3] asserts that, whenHis a subgroup of finite index in a groupG, there exists a system of common representatives of the right cosets and the left cosets ofHinG. Various proofs and generalisations, mainly involving combinatorial rather than grouptheoretical ideas, are known, and an excellent account
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
UNRAVELING THE ARCHITECTURE OF THE DORSAL RAPHE SYNAPTIC NEUROPIL USING HIGH-RESOLUTION NEUROANATOMY
Frontiers in Neural Circuits, 2014 The dorsal raphe nucleus (DRN), representing the main source of brain’s serotonin, is implicated in the pathophysiology and therapeutics of several mental disorders that can be debilitating and life-long including depression, anxiety and autism.
Mariano eSoiza-Reilly +3 more
doaj +1 more source
Creative Commons Licenses: empowering open access [PDF]
, 2016 No abstract ...
Margoni, Thomas, Peters, Diane M.
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Revisiting Maine’s lobster commons: rescaling political subjects [PDF]
, 2012 Calls for cross-scalar theoretical and methodological approaches are not new to commons scholarship. Such efforts might be hastened by channelling poststructuralist and critical theory perspectives through the geographic subfield of political ecology ...
Brewer, Jennifer F
core +1 more source
Cognitive constraints, contraction consistency, and the satisficing criterion [PDF]
, 2008 © 2007, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4 ...
Aleskerov +24 more
core +1 more source