Results 51 to 60 of about 491,182 (370)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Effect of CD4 count on Mycobacterium tuberculosis infection rates in people living with HIV: a comparative study in prison and community

Scientific Reports
To evaluate the impact of the CD4 count on ESAT6-CFP10 (EC) skin test, QuantiFERON-TB Gold In-tube test (QFT) and tuberculin skin test (TST) in a large prison and communities in Jiangsu Province among people living with HIV (PLHIV).
Peng Lu, Yilin Lian, Zhongqi Li, Kai Wu, Zhuping Xu, Hao Xue, Jincheng Li, Xing Zhang, Rong Wang, Xiaoyan Ding, Jingjing Pan, Hui Ding, Qiao Liu, Limei Zhu, Haitao Yang   +14 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The methodology for assessing smoking-attributed mortality based on All Causes of Death Surveillance in Tianjin, China, 2010–2015

Tobacco Induced Diseases, 2020
Introduction The All Causes of Death Surveillance (ACDS) system was used to measure smoking-attributed mortality by inserting questions on smoking on death certificates.
Wei Li*, Dezheng Wang*, Hui Zhang, Ying Zhang, Wenlong Zheng, Xiaodan Xue, Wenda Shen, Freddy Sitas, Guohong Jiang   +8 more
doaj   +1 more source

Optimal control of diseases in prison populations through screening policies of new inmates [PDF]

arXiv, 2020
In this paper, we study an optimal control problem of a communicable disease in a prison population. In order to control the spread of the disease inside a prison, we consider an active case-finding strategy, consisting on screening a proportion of new inmates at the entry point, followed by a treatment depending on the results of this procedure.
arxiv  

A Probabilistic Domain-knowledge Framework for Nosocomial Infection Risk Estimation of Communicable Viral Diseases in Healthcare Personnel: A Case Study for COVID-19 [PDF]

arXiv, 2021
Hospital-acquired infections of communicable viral diseases (CVDs) are posing a tremendous challenge to healthcare workers globally. Healthcare personnel (HCP) is facing a consistent risk of hospital-acquired infections, and subsequently higher rates of morbidity and mortality.
arxiv  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Time Evolution of Disease Spread on Networks with Degree Heterogeneity [PDF]

, 2007
Two crucial elements facilitate the understanding and control of communicable disease spread within a social setting. These components are, the underlying contact structure among individuals that determines the pattern of disease transmission; and the evolution of this pattern over time.
arxiv   +1 more source

Reconstructing transmission trees for communicable diseases using densely sampled genetic data [PDF]

Ann. Appl. Stat. 10 (2016) 395-417, 2014
Whole genome sequencing of pathogens from multiple hosts in an epidemic offers the potential to investigate who infected whom with unparalleled resolution, potentially yielding important insights into disease dynamics and the impact of control measures.
arxiv   +1 more source

Communicable Diseases and Outbreak Control.

Turkish journal of emergency medicine, 2015
Infectious disease during an emergency condition can raise the death rate 60 times in comparison to other causes including trauma. An epidemic, or outbreak, can occur when several aspects of the agent (pathogen), population (hosts), and the environment create an ideal situation for spread.
openaire   +3 more sources