Results 61 to 70 of about 491,182 (370)

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

The Spatial Features and Temporal Changes in the Gut Microbiota of a Healthy Chinese Population

Microbiology Spectrum, 2022
In this study, we aimed to understand the characteristics of the gut microbial composition in a healthy Chinese population and to evaluate if they differed across different regions.
Wen Zhang, Na Han, Tingting Zhang, Yujun Qiang, Xianhui Peng, Xiuwen Li, Biao Kan   +6 more
doaj   +1 more source

Scaling of contact networks for epidemic spreading in urban transit systems [PDF]

arXiv, 2020
Improved mobility not only contributes to more intensive human activities but also facilitates the spread of communicable disease, thus constituting a major threat to billions of urban commuters. In this study, we present a multi-city investigation of communicable diseases percolating among metro travelers.
arxiv  

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

National mortality burden due to communicable, non-communicable, and other diseases in Ethiopia, 1990–2015: findings from the Global Burden of Disease Study 2015 [PDF]

, 2017
Background: Ethiopia lacks a complete vital registration system that would assist in measuring disease burden and risk factors. We used the Global Burden of Diseases, Injuries, and Risk factors 2015 (GBD 2015) estimates to describe the mortality burden ...
A Misganaw, A Misganaw, Amare Deribew, AR Omran, Awoke Misganaw, Azmeraw T. Amare, B Weldearegawi, Biruck Desalegn Yirsaw, Central Statistical Agency (CSA) [Ethiopia] and ICF, CJL Murray, D Chandramohan, D Hailemariam, D Shamebo, D Shamebo, F Tesfaye, F Tesfaye, Federal Ministry of Health, Ethiopia, GA Biks, GBD 2013 Mortality and Causes of Death Collaborators, Gizachew Assefa Tessema, H Wang, Jed Blore, K Lulu, Kebede Deribe, Kristopher J. Krohn, L Chaker, M Naghavi, Mesoud Mohammed, MH Forouzanfar, Mohsen Naghavi, Molla Gedefaw, Muluken Dessalegn, NJ Kassebaum, P Byass, S Accorsi, S Kuruvilla, Semaw Ferede Abera, Solomon Abrha Damtew, T Araya, Tilahun N. Haregu, Tolesa Bekele, Tom Achoki, W Deressa, Yibeltal Assefa, Yihunie Lakew, Yohannes Adama Melaku   +45 more
core   +2 more sources

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Modeling the burden of long COVID in California with quality adjusted life-years (QALYS)

Scientific Reports
Individuals infected with SARS-CoV-2 may develop post-acute sequelae of COVID-19 (“long COVID”) even after asymptomatic or mild acute illness. Including time varying COVID symptom severity can provide more informative burden estimates for public health ...
Sophie Zhu, Kalyani McCullough, Jake M. Pry, Seema Jain, Lauren A. White, Tomás M. León   +5 more
doaj   +1 more source

Clinical characteristics and risk factors of Hepatitis E virus infection in Zhejiang Province: a multicenter case–control study

Frontiers in Public Health
IntroductionHepatitis E (HE), caused by the Hepatitis E virus (HEV), is a significant cause of acute viral hepatitis globally and a major public health concern, particularly in specific high-prevalence areas in China, which have diverse transmission ...
Yijuan Chen, Jian Gao, Wanwan Sun, Weiping Zhu, Pingping Wang, Xiaobin Ren, Yumeng Wu, Jianli Zhang, Ziping Miao   +8 more
doaj   +1 more source

Have purpose‐built vaccine refrigerators reduced the cost of vaccine losses in South Australia?

Australian and New Zealand Journal of Public Health, 2012
Objectives: There is limited epidemiological data on the performance of different refrigerator types for vaccine storage in the real world. This study aims to measure if the introduction of purpose‐built vaccine refrigerators has reduced the cost of ...
Katina D'Onise, Sara Almond, Breda MacDonald, Maureen Watson, Sophie Scrimgeour   +4 more
doaj   +1 more source