Results 71 to 80 of about 491,182 (370)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Newly estimated disability weights for 196 health states in Hubei Province, China
Population Health MetricsBackground The disability weight (DW) reflects the severity of non-fatal outcomes and is an important parameter in calculating the burden of disease. However, the universality of the global, national, or subnational DWs remains controversial.
Mengge Zhou +7 more
doaj +1 more source
BMC Medicine, 2017 Background The United Nation’s Sustainable Development Goals for 2030 include reducing premature mortality from non-communicable diseases (NCDs) by one third.
Yichong Li +14 more
doaj +1 more source
Gut Microbes, 2022 Vibrio fluvialis is a halophilic Gram-negative bacterium regarded as an emerging unusual enteric pathogen of increasing public health concern. Our previous work has identified two type VI secretion systems (T6SSs) in V. fluvialis, VflT6SS1, and VflT6SS2,
Yuanming Huang +10 more
doaj +1 more source
, 2018 TheSouth Carolina Bureau of Communicable Disease Prevention and Control publishes Epi Notes, with articles on epidemiology of reportable conditions; surveillance and reporting of diseases/conditions, outbreaks, and events of public health significance ...
South Carolina Bureau of Communicable Disease Prevention and Control
core
Communication and communicable disease control: lessons from Ebola virus disease. [PDF]
, 2015 In her article “Ebola, Team Communication, and Shame: But Shame on Whom?” Shannon (2015) describes communication failures that contributed to delayed diagnosis—and, arguably, to the death—of the first patient in the United States to present with Ebola ...
Gilbert, G. L., Kerridge, I
core +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Deterministic Models in Epidemiology: From Modeling to Implementation [PDF]
arXiv, 2020 The abrupt outbreak and transmission of biological diseases has always been a long-time concern of humankind. For long, mathematical modeling has served as a simple and yet efficient tool to investigate, predict, and control spread of communicable diseases through individuals.
arxiv
Population mobility, well-mixed clustering and disease spread: a look at COVID-19 Spread in the United States and preventive policy insights [PDF]
arXiv, 2023 The epidemiology of pandemics is classically viewed using geographical and political borders; however, these artificial divisions can result in a misunderstanding of the current epidemiological state within a given region. To improve upon current methods, we propose a clustering algorithm which is capable of recasting regions into well-mixed clusters ...
arxiv
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source