Results 81 to 90 of about 520,835 (347)

Comparison of novel and traditional anthropometric indices in Eastern-China adults: which is the best indicator of the metabolically obese normal weight phenotype?

BMC Public Health
Background People with the metabolically obese normal weight (MONW) phenotype have been confirmed to significantly increase the risk of unfavorable health consequences.
Yijia Chen, Chenchen Wang, Qiannan Sun, Qing Ye, Hairong Zhou, Zhenzhen Qin, Shengxiang Qi, Weiwei Wang, Xin Hong   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Associations of changes in waist circumference and BMI with variation of fasting blood glucose among middle aged and elderly residents at high cardiovascular risk: a follow-up study in Jiangsu province

Zhongguo gonggong weisheng
Objective To investigate associations of changes in waist circumference (WC) and body mass index (BMI) with the variation of fasting blood glucose among middle aged and elderly residents with high cardiovascular risk.
Xun WU, Yu QIN, Jian SU, Lulu CHEN, Lan CUI, Ran TAO, Jinyi ZHOU   +6 more
doaj   +1 more source

Promotion of access to essential medicines for Non-Communicable Diseases: Practical implications of the UN Political Declaration [PDF]

, 2013
Access to medicines and vaccines to prevent and treat non-communicable diseases (NCDs) is unacceptably low worldwide. In the 2011 UN political declaration on the prevention and control of NCDs, heads of government made several commitments related to ...
Abdraimova, Alleyne, Atun, Barrington, Bigdeli, Cameron, Cameron, Cameron, Caudron, Chaudhuri, Colombo, Di Cesare, Downing, Faith N Mwangi-Powell, Ford, Ford, Frenk, Frost, Gale, Gilks, Goroff, Hans V Hogerzeil, Hardon, Heath, Hogerzeil, Hogerzeil, Jonathan Liberman, Kanavos, Kishore, Laing, Liberman, Lim, Lonn, Lu, Luiz, Marquez, Maxmen, Mills, Moodie, Moon, Outterson, Panchagnula, Perehudoff, Quick, Rachel Kiddell-Monroe, Reddy, Roderick, Sakthi Selvaraj, Sandeep P Kishore, Sanne, Smith, Szabo, Tido von Schoen-Angerer, Twagirumukiza, Twagirumukiza, Veronika J Wirtz, Wagner, Wald, Waning, Yusuf, ‘t Hoen   +60 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Have purpose‐built vaccine refrigerators reduced the cost of vaccine losses in South Australia?

Australian and New Zealand Journal of Public Health, 2012
Objectives: There is limited epidemiological data on the performance of different refrigerator types for vaccine storage in the real world. This study aims to measure if the introduction of purpose‐built vaccine refrigerators has reduced the cost of ...
Katina D'Onise, Sara Almond, Breda MacDonald, Maureen Watson, Sophie Scrimgeour   +4 more
doaj   +1 more source

Reimagining WHO: Leadership and Action for a New Director-General [PDF]

, 2017
Three candidates to be the next WHO Director-General remain: Tedros Adhanom Ghebreyesus, David Nabarro, and Sania Nishtar. The World Health Assembly’s ultimate choice will lead an Organization facing daunting internal and external challenges, from its ...
Friedman, Eric A., Gostin, Lawrence O.
core   +2 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Joint Effect of Central Obesity and Family History on Hypertension in Type 2 Diabetes: A Cross-Sectional Study in China

Diabetes, Metabolic Syndrome and Obesity
Xiangyu Chen, Lijin Chen, Ruying Hu, Weiyuan Yao, Zhimin Ma, Jieming Zhong Department of Non-Communicable Disease Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, 310051, People’s Republic of ...
Chen X, Chen L, Hu R, Yao W, Ma Z, Zhong J   +5 more
doaj  

Gap Analysis of Environmental Health Research in Malawi : Report to the National Commission of Science and Technology [PDF]

, 2010
The aim of this consultancy was to assess the current gaps in research for the environmental health sector in Malawi, and to recommend research priorities and an effective action plan to address these ...
Lungu, Kingsley, Morse, Tracy, Taulo, Steven   +2 more
core