Results 41 to 50 of about 222,694 (251)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Autoconscience professionnelle des enseignants de langues étrangères – comment outiller les étudiants en formation initiale ?

Glottodidactica, 2022
The aim of the text is to discuss the possibilities of developing professional self-awareness at the stage of initial education of foreign language teachers.
Jolanta Sujecka-Zając, Krystyna Szymankiewicz   +1 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Compétence, savoir expert et expertise : l’exemple d’Adalhard de Corbie (752-826)

, 2016
International ...
openaire   +3 more sources

Quelle relation entre l’écrit académique et l’écrit professionnel? Une étude de cas dans le domaine du travail social [What is the relationship between academic writing and professional writing? A case study in the field of social work] [PDF]

, 2012
Beaucoup d'étudiants, dans l'enseignement supérieur, suivent des cours à orientation professionnelle. Cet article se focalise sur un projet d’« ethnographie de texte », concernant l’écriture des assistants sociaux pendant leur formation et sur leur ...
Lillis, Theresa, Rai, Lucy
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Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

L’EVALUATION DES COMPETENCES DES MANAGERS DE PROXIMITE DE L’EDUCATION-FORMATION : UN CHANTIER POUR BATIR L’ECOLE DE LA QUALITE ET LA PERFORMANCE

Revue Marocaine de Recherche en Management et Marketing, 2017
La vision stratégique de la réforme 2015-2030 réalisée par le Conseil Supérieur de l’Éducation, la Formation et la Recherche Scientifique(CSEFRS)intitulée«Pour une école de l’équité, de la qualité et de la promotion», est très ambitieuse ...
GUEDIRA MOHAMMED
doaj  

Politique de gestion des ressources humaines - règlement n°18 [PDF]

, 1998
Politique de gestion des ressources humaines - règlement numéro 18 ; ; Annexe A : Répertoire des habiletés professionnelles et des comportements observables ; Annexe B : Personnel professionnel non-enseignant - Profil des compétences attendues ...

core