Results 51 to 60 of about 167,675 (289)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

NUMERICAL CALCULATION OF THE HYDROLIQUID LEAKAGE THROUGH THE RADIAL CLEARANCE OF THE CONNECTED ELEMENTS ON THE TOWER CRANE HYDROCILINDER

Вестник СибАДИ, 2019
Introduction. The authors present the numerical calculation of the hydro-liquid leakage throughthe radial clearance of the “piston - hydraulic cylinder” conjugate node on the basis of determiningthe sealing elements’ resource of the tower crane hydraulic
D. A. Potakhov, Ya. S. Vatulin
doaj   +1 more source

Fabrication of Highly Compacted Green Body Using Multi-Sized Al Powder under a Centrifugal Force

Journal of Manufacturing and Materials Processing, 2022
This study investigates the application of centrifugal force for the compaction of metal powder. Previous studies using the centrifugal force for manufacturing the green bodies were focused on fine powders with narrow particle size distribution or binary
Bakytzhan Sariyev, Abilkhairkhan Aldabergen, Dulat Akzhigitov, Boris Golman, Christos Spitas   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Compared performance of penetrometers and effect of soil water content on penetration resistance measurements [PDF]

Revista Brasileira de Ciência do Solo, 2014
Modern agriculture techniques have a great impact on crops and soil quality, especially by the increased machinery traffic and weight. Several devices have been developed for determining soil properties in the field, aimed at managing compacted areas ...
Edison Aparecido Mome Filho, Alvaro Pires da Silva, Getulio Coutinho Figueiredo, Fernando Henrique Setti Gimenes, André Cesar Vitti   +4 more
doaj   +1 more source

Along the Process Chain to Probiotic Tablets: Evaluation of Mechanical Impacts on Microbial Viability

Pharmaceutics, 2020
Today, probiotics are predominantly used in liquid or semi-solid functionalized foods, showing a rapid loss of cell viability. Due to the increasing spread of antibiotic resistance, probiotics are promising in pharmaceutical development because of their ...
Karl Vorländer, Ingo Kampen, Jan Henrik Finke, Arno Kwade   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Compactness and collective compactness in spaces of compact operators

Journal of Mathematical Analysis and Applications, 1981
AbstractThis is a study of compactness in (a) spaces Kb(X, Y) of compact linear operators, (b) injective tensor products X \̃boϵ Y, and (c) spaces Lc(X, Y) of continuous linear operators, and its various relationships with equicontinuity and collective compactness.
openaire   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source