Results 71 to 80 of about 161,652 (234)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Study of the Effect of the Floating Die Compaction on Mechanical Properties of Titanium Foams
Metals, 2020 Titanium (Ti) and its alloys are used for biomedical applications because of their high resistance to corrosion, good strength-to-weight ratio, and high fatigue resistance.
Sergio Sauceda +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Probing the Impact of Porosity on Swelling Kinetics of Hydrophilic Matrices
British Journal of Pharmacy, 2017 The aim of the present investigation was to understand the swelling behaviour of HPMC and PEO-based matrices and to evaluate the impact of porosity on the swelling kinetics.
Muhammad S Asim +2 more
doaj +1 more source
Pharmaceutics, 2020 The present work aims to understand the crystallographic basis of the mechanical behavior of rivaroxaban-malonic acid cocrystal (RIV-MAL Co) in comparison to its parent constituents, i.e., rivaroxaban (RIV) and malonic acid (MAL). The mechanical behavior
Dnyaneshwar P. Kale +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
The Recovery of Soils after Compaction: A laboratory investigation into the effect of wet/dry cycles on bulk density and soil hydraulic functions [PDF]
, 2009 Van den Akker et al. (2003) stated that “European subsoils are more threatened than ever in history” in an editorial referring to the results of the European Union concerted action “Experiences with the impact of subsoil compaction on soil crop growth ...
O'Keefe, Sorche
core +4 more sources
LandMajor losses of agricultural production and soils are caused by erosion, which is especially pronounced on hillslopes due to specific hydrological processes and heterogeneity.
Jasmina Defterdarović +12 more
doaj +1 more source
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source