Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Integral type operators from normal weighted Bloch spaces to QT,S spaces
Journal of Hebei University of Science and Technology, 2016 Operator theory is an important research content of the analytic function space theory. The discussion of simultaneous operator and function space is an effective way to study operator and function space.
Yongyi GU, Wenjun YUAN, Fanning MENG
doaj +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Multicultivar and multivariate study of the natural variation for grapevine bunch compactness
, 2015 Background and Aims Grapevine bunch compactness is an important trait with impact on fruit quality, mainly affecting the susceptibility to bunch rot.
J. Tello +6 more
semanticscholar +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Research on the Compactness of Lunar Soil Simulant Based on Static Cone Penetration Test
Applied SciencesThe shear strength and bearing characteristics of lunar soil have a strong connection with its compactness. The compactness varies significantly with depth and has an important effect on engineering activities on the lunar surface.
Yuxin Zhang +5 more
doaj +1 more source
On the compactness of space $L^p(p>0)$ and its application to integral equations [PDF]
, 1951 Masatsugu Tsuji
openalex +1 more source
A new method for assessment of bunch compactness using automated image analysis
, 2015 Background and Aims Bunch compactness is a key feature determining grape and wine composition because tight bunches show a less homogeneous ripening, and are prone to greater fungal disease incidence.
S. Cubero +7 more
semanticscholar +1 more source