Results 71 to 80 of about 44,228 (247)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Topological approach to analyzing compactness and connectivity of settlement systems considering terrain constraints (case study of the Saratov Region) [PDF]
Известия Саратовского университета. Новая серия: Серия Науки о ЗемлеThe article examines the application of topological concepts for analysing the structure and assessing the compactness of a regional settlement system.
Danilov, Vladimir Anatolievich +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Journal of the London Mathematical SocietyAbstractWe demonstrate that the technology of Radin forcing can be used to transfer compactness properties at a weakly inaccessible but not strong limit cardinal to a strongly inaccessible cardinal. As an application, relative to the existence of large cardinals, we construct a model of set theory in which there is a strongly inaccessible cardinal ...
Tom Benhamou, Jing Zhang
openaire +2 more sources
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Evaluation of concrete mechanical strength through porosity
Materiales de Construccion, 2004 The increasing on voids or pores in any material - if the rest of characteristics remains equal -always causes a decrease in their mechanical strength since the ratio volume/resistant mass is lower Following all these fact a well known conclusion rises ...
M. Olivares +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Revista Brasileira de Ciência do Solo, 2004 O uso intensivo do solo, aliado a condições inadequadas de manejo, concorre para a deterioração de suas propriedades físicas e isso se deve, principalmente, às modificações em sua estrutura.
N. Olszevski +5 more
doaj +1 more source