Results 11 to 20 of about 448,500 (267)

An exposure‐response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis

CPT: Pharmacometrics & Systems Pharmacology, 2022
The efficacy of ponesimod and teriflunomide for the treatment of relapsing multiple sclerosis (MS) was compared in a randomized phase III trial. This study explores the exposure‐response (E‐R) relationships of efficacy end points (annualized relapse rate
Belén Valenzuela, Per Olsson Gisleskog, Italo Poggesi, Tatiana Sidorenko, Michel Burcklen, Hilke Kracker, Juan Jose Pérez‐Ruixo   +6 more
doaj   +1 more source

On the Mortality of Companies [PDF]

Entropy, 2022
Using data from both the US and UK we examine the survival and mortality of companies in both the early stage or start-up and mature phases. The shape of the mortality curve is broadly similar to that of humans. Even small single cellular organisms such as rotifers have a similar shape.
Peter Richmond, Bertrand M. Roehner
openaire   +3 more sources

Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau

Acta Neuropathologica Communications, 2018
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy.
Jeroen van Ameijde, Rosa Crespo, Roosmarijn Janson, Jarek Juraszek, Berdien Siregar, Hanneke Verveen, Imke Sprengers, Tariq Nahar, Jeroen J. Hoozemans, Stefan Steinbacher, Roland Willems, Lore Delbroek, Marianne Borgers, Koen Dockx, Kristof Van Kolen, Marc Mercken, Gabriel Pascual, Wouter Koudstaal, Adrian Apetri   +18 more
doaj   +1 more source

α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins

Nature Communications, 2019
The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders.
G. Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex, David S. Bredt   +7 more
doaj   +1 more source

GENERALIZED ERYTHEMATOUS-URTICARIAL DERMATITIS AND RESPIRATORY INFECTIONAS A MANIFESTATION OF COMBINED PARVOVIRUS B19 AND MYCOPLASMA PNEUMONIAE INFECTION IN A 2-YEAR-OLD CHILD

Детские инфекции (Москва), 2018
The article describes the clinical case of combined skin lesions in the form of generalized erythematous-urticarial dermatitis and the respiratory tract in the form of rhinoadenopharyngitis, simple bronchitis, in a child of 2 years.
G. V. Petrova, S. S. Agapova, M. V. Mozzhukhina, E. P. Tymoshenko, N. S. Pavlov, E. P. Kudryavtzeva, N. P. Makina, M. V. Shcherbakova   +7 more
doaj   +1 more source

Experience of Veno-venous Extracorporeal Membrane Oxygenation in a Pregnant Woman With Severe Acute Respiratory Distress Syndrome Caused by the SARSCoV-2 Virus

Неотложная медицинская помощь, 2021
Pregnant women occupy a special place in the incidence structure of the new coronavirus infection COVID -19. Taking into account the likelihood of a more severe course of acute respiratory syndrome (ARDS) in this group, it is worth remembering the ...
M. A. Kurtser, E. I. Spiridonova, S. V. Tsarenko, P. M. Bagdasaryan, E. A. Baranova, A. V. Oskolkov, A. V. Grapova, O. G. Arguzova, Yu. Yu. Kutakova, Yu. O. Shapovalova, D. V. Yeremin, M. V. Antonets, A. V. Panin, N. V. Petrovskaya, I. V. Platitsyn, A. G. Serobyan, G. D. Shulyak   +16 more
doaj   +1 more source

A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities

Acta Neuropathologica Communications, 2018
Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somatically mutated VH5 ...
Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs, Margot van Winsen, Martin H. Koldijk, David Zuijdgeest, Marianne Borgers, Koen Dockx, Esther J. M. Stoop, Wenli Yu, Els C. Brinkman-van der Linden, Kimberley Ummenthum, Kristof van Kolen, Marc Mercken, Stefan Steinbacher, Donata de Marco, Jeroen J. Hoozemans, Ian A. Wilson, Wouter Koudstaal, Jaap Goudsmit   +32 more
doaj   +1 more source

Community Pharmacists’ Motivation and Barriers to Providing and Billing Patient Care Services

Pharmacy, 2020
Recently, California (CA) pharmacists’ scope of practice has expanded to include independently prescribing self-administered hormonal contraceptives, nicotine replacement therapy medications, travel health medications, routine vaccinations, naloxone ...
Liesl D. Reyes, Jenny Hong, Christine Lin, Jeffrey Hamper, Lisa Kroon   +4 more
doaj   +1 more source

Industrial application of heat- and mass balance model for fluid-bed granulation for technology transfer and design space exploration

International Journal of Pharmaceutics: X, 2019
This work demonstrates the application of state-of-the-art modeling techniques in pharmaceutical manufacturing for fluid bed granulation at varying scales to successfully predict process conditions and ultimately replace experiments during a technology ...
David R. Ochsenbein, Matthew Billups, Bingbing Hong, Elisabeth Schäfer, Alexander J. Marchut, Olav K. Lyngberg   +5 more
doaj   +1 more source

Clinical case of nebulized surfactant therapy for severe COVID-19-associated pneumonia at the 2nd stage of rehabilitation treatment

Медицинский совет, 2021
The development of an effective and safe drug for the treatment of patients with COVID-19 is currently an urgent task for the global medical community.
I. Yu. Stulikova, A. V. Tsvetkova, E. S. Koneva, T. V. Shapovalenko   +3 more
doaj   +1 more source