Results 31 to 40 of about 448,500 (267)

The acute adverse health effects of kratom: an evaluation of case reports

Frontiers in Pharmacology
Mitragyna speciosa, commonly known as kratom, has gained popularity in the United States due to its stimulant and analgesic effects. Allegations of kratom-associated adverse health effects, primarily based on case reports/series, have obtained media ...
Sarah Smallets, Sydney Litvin, Grayson Abele, Sarah Kirsh, Dennis Paustenbach   +4 more
doaj   +1 more source

Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures

SLAS Discovery, 2023
Recent advances in automated microscopy and image analysis enables quantitative profiling of cellular phenotypes (Cell Painting). It paves the way for studying the broad effects of chemical perturbations on biological systems at large scale during lead ...
Alemu Takele Assefa, Bie Verbist, Emmanuel Gustin, Danielle Peeters   +3 more
doaj   +1 more source

Animal‐Assisted Activities With Therapy Dogs in Pediatric Oncology: A Multicenter Survey of the Current Status, Implementation, and Challenges in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Animal‐assisted activities (AAAs) with therapy dogs have shown positive effects on patient well‐being and quality of life in various areas of medicine, including pediatric oncology. However, research on this topic is limited. The aim of this study is to present the current status of AAA in pediatric oncology in Germany, Austria, and
Jan‐Marius Wedig, Birgit Burkhardt, Christof M. Kramm, Kira Ostermann, Sarah C. Goretzki, Uta Dirksen, Nico Kurpiers, Michael M. Schündeln   +7 more
wiley   +1 more source

INFLAMMATORY MYOFIBROBLASTIC TUMOR OF THE BLADDER

Вестник урологии, 2018
Inflammatory myofibroblastic tumor (IMT) is a neoplasm of low malignant potential. We report a case of inflammatory myofibroblastic tumor of the urinary bladder in a 30-year-old female treated with TURB.
A. S. Popko, K. L. Lokshin, L. A. Shestakova, V. N. Shirshov   +3 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Administering Blinatumomab via Continuous Intravenous Infusion in Pediatric Patients—A Single‐Institution Retrospective Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab, a CD19xCD3 bispecific T‐cell engager, has become standard therapy for children with de novo B‐cell acute lymphoblastic leukemia (B‐ALL). This retrospective review describes the experience of blinatumomab administration in pediatric patients.
Julia M. Hurley, Ryleigh Krueger, Kellie Joyce, James Stanley, Mary Waskerwitz‐Freyer, Marielle Klunder, David J. Hoogstra   +6 more
wiley   +1 more source

Pancreatic enzymes in the treatment of painful chronic pancreatitis with moderate exocrine insufficiency

Медицинский совет, 2013
The term chronic pancreatitis (CP) is used to denote a group of chronic diseases of the pancreas of various etiology, predominantly inflammatory, with several phases of progress, and characterized by focal, segmental or diffuse degenerative and ...
M. I. Shchyokina, M. S. Panchuk
doaj   +1 more source

Liver as the target organ: what we can do to help the patient

Медицинский совет, 2013
Liver diseases of various origin are a common cause of morbidity and mortality. The pathogenetic mechanism of hepatocyte damage consists in the destruction of the membrane structure in a certain way. It is recommended to use drugs exhibiting revitalizing
E. B. Grishchenko, M. I. Shchyokina
doaj   +1 more source

Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

BMC Molecular and Cell Biology, 2020
Background Although several studies demonstrate prion-like properties of Tau fibrils, the effect of size in the seeding capacity of these aggregates is not fully understood.
André Marreiro, Kristof Van Kolen, Cristiano Sousa, Liesbet Temmerman, Bruno Vasconcelos, Rosa Crespo-Rodriguez, Jan R. T. van Weering, Debby Van Dam, Peter P. De Deyn, Adrian Apetri, Liliane Schoofs, Marc H. Mercken   +11 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source