Results 31 to 40 of about 54,753 (262)

Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis

Stem Cell Reports, 2017
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee   +20 more
doaj   +1 more source

Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases [PDF]

Developmental Dynamics, 2017
Epithelial–mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread.
Francart, Marie‐emilie, Lambert, Justine, Vanwynsberghe, Aline, Thompson, Erik, Bourcy, Morgane, Polette, Myriam, Gilles, Christine   +6 more
openaire   +3 more sources

Sieve Elements and Companion Cells—Traffic Control Centers of the Phloem [PDF]

The Plant Cell, 1999
Of all the intricate cell–cell interactions in nature, those between the sieve element (SE) and its companion cell (CC) rank among the most complex and mysterious. Mature SEs are enucleate and retain only a highly degenerate cytoplasm, yet they can remain viable and functional for decades ([
, Oparka, , Turgeon
openaire   +2 more sources

Development and characterization of mouse anti-canine PD-L1 monoclonal antibodies and their expression in canine tumors by immunohistochemistry in vitro

Veterinary Quarterly, 2023
Immune escape is the hallmark of carcinogenesis. This widely known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy.
Sirintra Sirivisoot, Chatikorn Boonkrai, Tossapon Wongtangprasert, Tanapati Phakham, Phijitra Muanwein, Trairak Pisitkun, Chenphop Sawangmake, Araya Radtanakatikanon, Anudep Rungsipipat   +8 more
doaj   +1 more source

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

Stem Cell Reports, 2015
The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease.
Sathidpak Nantasanti, Bart Spee, Hedwig S. Kruitwagen, Chen Chen, Niels Geijsen, Loes A. Oosterhoff, Monique E. van Wolferen, Nicolas Pelaez, Hille Fieten, Richard W. Wubbolts, Guy C. Grinwis, Jefferson Chan, Meritxell Huch, Robert R.G. Vries, Hans Clevers, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus   +18 more
doaj   +1 more source

Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes [PDF]

Science, 2012
Intergenerational Transposable Shutdown Transposable elements (TEs) are a potential threat, especially to the germline genome. In many eukaryotes, TEs are shut down by DNA methylation and/or small-RNA–mediated silencing.
Ibarra, Christian A, Feng, Xiaoqi, Schoft, Vera K, Hsieh, Tzung-Fu, Uzawa, Rie, Rodrigues, Jessica A, Zemach, Assaf, Chumak, Nina, Machlicova, Adriana, Nishimura, Toshiro, Rojas, Denisse, Fischer, Robert L, Tamaru, Hisashi, Zilberman, Daniel   +13 more
openaire   +3 more sources

Organoids: a promising new in vitro platform in livestock and veterinary research

Veterinary Research, 2021
Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pluripotent stem cells.
Soumya K. Kar, Jerry M. Wells, Esther D. Ellen, Marinus F. W. te Pas, Ole Madsen, Martien A. M. Groenen, Henri Woelders   +6 more
doaj   +1 more source

Hematology and clinical biochemistry reference intervals for companion pigs using the ADVIA 2120 and Cobas c501 [PDF]

PeerJ
Background The majority of published reference intervals for hematology and clinical biochemistry in pigs are generated from a sample group that is demographically different from companion pigs, and as such may not be transferable.
Deanna M. W. Schaefer, Ricardo Videla, Joe S. Smith, Pierre-Yves Mulon, Bente Flatland, Xiaojuan Zhu   +5 more
doaj   +2 more sources

Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells

PLOS ONE, 2015
Lymph node and spleen cells of mice doubly immunized by epicutaneous and intravenous hapten application produce a suppressive component that inhibits the action of the effector T cells that mediate contact sensitivity reactions. We recently re-investigated this phenomenon in an immunological system.
Bryniarski, Krzysztof, Ptak, Włodzimierz, Martin, Emilia, Nazimek, Katarzyna, Szczepanik, Marian, Sanak, Marek, Askenase, Philip W.   +6 more
openaire   +6 more sources

A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. [PDF]

PLoS Genetics, 2012
Flowering time relies on the integration of intrinsic developmental cues and environmental signals. FLC and its downstream target FT are key players in the floral transition in Arabidopsis.
Hongchun Yang, Zhifu Han, Ying Cao, Di Fan, Hong Li, Huixian Mo, Yi Feng, Lei Liu, Zheng Wang, Yanling Yue, Sujuan Cui, She Chen, Jijie Chai, Ligeng Ma   +13 more
doaj   +1 more source