Results 11 to 20 of about 5,126,546 (294)

Hypothalamic perifornical Urocortin-3 neurons modulate defensive responses to a potential threat stimulus

open access: yesiScience, 2021
Summary: Defensive behaviors are evolved responses to threat stimuli, and a potential threat elicits risk assessment (RA) behavior. However, neural mechanisms underlying RA behavior are hardly understood.
Noriko Horii-Hayashi   +5 more
doaj   +1 more source

Characterization of companion animal pluripotent stem cells [PDF]

open access: yesCytometry Part A, 2017
AbstractPluripotent stem cells have the capacity to grow indefinitely in culture and differentiate into derivatives of the three germ layers. These properties underpin their potential to be used in regenerative medicine. Originally derived from early embryos, pluripotent stem cells can now be derived by reprogramming an adult cell back to a pluripotent
Y Z, Paterson, C, Kafarnik, D J, Guest
openaire   +2 more sources

Companion Animal Model in Translational Oncology; Feline Oral Squamous Cell Carcinoma and Canine Oral Melanoma

open access: yesBiology, 2021
Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development.
Antonio Giuliano
doaj   +1 more source

Vagrant Stem Cells Draft Their Gene Companions [PDF]

open access: yesCell Stem Cell, 2010
In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
Bonig, Halvard, Papayannopoulou, Thalia
openaire   +2 more sources

The companions: regulatory T cells and gene therapy [PDF]

open access: yesImmunology, 2009
SummaryUndesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial.
Saman, Eghtesad   +2 more
openaire   +2 more sources

Cell Therapy in Veterinary Medicine as a Proof-of-Concept for Human Therapies: Perspectives From the North American Veterinary Regenerative Medicine Association

open access: yesFrontiers in Veterinary Science, 2021
In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains.
Boaz Arzi   +10 more
doaj   +1 more source

A pocket companion to cell-free DNA (cfDNA) preanalytics

open access: yesTumor Biology, 2023
The cumulative pool of cell-free DNA (cfDNA) molecules within bodily fluids represents a highly dense and multidimensional information repository. This “biological mirror” provides real-time insights into the composition, function, and dynamics of the diverse genomes within the body, enabling significant advancements in personalized molecular medicine.
Abel J, Bronkhorst, Stefan, Holdenrieder
openaire   +2 more sources

Favipiravir Suppresses Zika Virus (ZIKV) through Activity as a Mutagen

open access: yesMicroorganisms, 2023
In a companion paper, we demonstrated that the nucleoside analogue favipiravir (FAV) suppressed Zika virus (ZIKV) replication in three human-derived cell lines—HeLa, SK-N-MC, and HUH-7.
Evelyn J. Franco   +5 more
doaj   +1 more source

Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease

open access: yesCells, 2020
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation.
Hedwig S. Kruitwagen   +22 more
doaj   +1 more source

Induction of sucrose synthase in the phloem of phytoplasma infected maize

open access: yesBiologia Plantarum, 2011
In this study, we have analyzed the expression of the low oxygen inducible sucrose synthase isozyme SH1 (SUS-SH1) in the phloem of maize (Zea mays L.) infected with maize bushy stunt phytoplasma.
J. Brzin   +3 more
doaj   +1 more source

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