Results 11 to 20 of about 59,612 (299)
Biology, 2021 Companion animals with naturally occurring cancers can provide an advantageous model for cancer research and in particular anticancer drug development.
Antonio Giuliano
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Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes [PDF]
Science, 2012 Intergenerational Transposable Shutdown Transposable elements (TEs) are a potential threat, especially to the germline genome. In many eukaryotes, TEs are shut down by DNA methylation and/or small-RNA–mediated silencing.
Ibarra, Christian A +13 more
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A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. [PDF]
PLoS Genetics, 2012 Flowering time relies on the integration of intrinsic developmental cues and environmental signals. FLC and its downstream target FT are key players in the floral transition in Arabidopsis.
Hongchun Yang +13 more
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iScience, 2021 Summary: Defensive behaviors are evolved responses to threat stimuli, and a potential threat elicits risk assessment (RA) behavior. However, neural mechanisms underlying RA behavior are hardly understood.
Noriko Horii-Hayashi +5 more
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Characterization of companion animal pluripotent stem cells [PDF]
Cytometry Part A, 2017 AbstractPluripotent stem cells have the capacity to grow indefinitely in culture and differentiate into derivatives of the three germ layers. These properties underpin their potential to be used in regenerative medicine. Originally derived from early embryos, pluripotent stem cells can now be derived by reprogramming an adult cell back to a pluripotent
Y Z, Paterson, C, Kafarnik, D J, Guest
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The companions: regulatory T cells and gene therapy [PDF]
Immunology, 2009 SummaryUndesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial.
Saman, Eghtesad +2 more
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Vagrant Stem Cells Draft Their Gene Companions [PDF]
Cell Stem Cell, 2010 In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
Bonig, Halvard, Papayannopoulou, Thalia
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Frontiers in Veterinary Science, 2021 In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains.
Boaz Arzi +10 more
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A pocket companion to cell-free DNA (cfDNA) preanalytics
Tumor Biology, 2023 The cumulative pool of cell-free DNA (cfDNA) molecules within bodily fluids represents a highly dense and multidimensional information repository. This “biological mirror” provides real-time insights into the composition, function, and dynamics of the diverse genomes within the body, enabling significant advancements in personalized molecular medicine.
Abel J, Bronkhorst, Stefan, Holdenrieder
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Favipiravir Suppresses Zika Virus (ZIKV) through Activity as a Mutagen
Microorganisms, 2023 In a companion paper, we demonstrated that the nucleoside analogue favipiravir (FAV) suppressed Zika virus (ZIKV) replication in three human-derived cell lines—HeLa, SK-N-MC, and HUH-7.
Evelyn J. Franco +5 more
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