Results 41 to 50 of about 56,758 (258)
Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis
Stem Cell Reports, 2017 Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure.
Hedwig S. Kruitwagen +20 more
doaj +1 more source
Epithelial–mesenchymal plasticity and circulating tumor cells: Travel companions to metastases [PDF]
Developmental Dynamics, 2017 Epithelial–mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread.
Francart, Marie‐emilie +6 more
openaire +3 more sources
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
Stem Cell Reports, 2015 The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease.
Sathidpak Nantasanti +18 more
doaj +1 more source
Hematology and clinical biochemistry reference intervals for companion pigs using the ADVIA 2120 and Cobas c501 [PDF]
PeerJBackground The majority of published reference intervals for hematology and clinical biochemistry in pigs are generated from a sample group that is demographically different from companion pigs, and as such may not be transferable.
Deanna M. W. Schaefer +5 more
doaj +2 more sources
Organoids: a promising new in vitro platform in livestock and veterinary research
Veterinary Research, 2021 Organoids are self-organizing, self-renewing three-dimensional cellular structures that resemble organs in structure and function. They can be derived from adult stem cells, embryonic stem cells, or induced pluripotent stem cells.
Soumya K. Kar +6 more
doaj +1 more source
Veterinary Quarterly, 2023 Immune escape is the hallmark of carcinogenesis. This widely known mechanism is the overexpression of immune checkpoint ligands, such as programmed cell death protein 1 and programmed death-ligand 1 (PD-1/PD-L1), leading to T cell anergy.
Sirintra Sirivisoot +8 more
doaj +1 more source
A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. [PDF]
PLoS Genetics, 2012 Flowering time relies on the integration of intrinsic developmental cues and environmental signals. FLC and its downstream target FT are key players in the floral transition in Arabidopsis.
Hongchun Yang +13 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille +9 more
wiley +1 more source