Results 81 to 90 of about 237,053 (294)

Alternative donor hematopoietic stem cell transplantation for sickle cell disease

Blood Advances, 2017
: Most patients who could be cured of sickle cell disease (SCD) with stem cell transplantation do not have a matched sibling donor. Successful use of alternative donors, including mismatched family members, could provide a donor for almost all patients ...
Andrew L. Gilman, Michael J. Eckrich, Stacy Epstein, Carrie Barnhart, Mark Cannon, Tracy Fukes, Michelle Hyland, Krishna Shah, Darci Grochowski, Elizabeth Champion, Anastasia Ivanova   +10 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

A Planetary Mass Companion to the K0 Giant HD 17092 [PDF]

, 2007
We report the discovery of a substellar-mass companion to the K0-giant HD 17092 with the Hobby-Eberly Telescope. In the absence of any correlation of the observed 360-day periodicity with the standard indicators of stellar activity, the observed radial ...
A. Niedzielski, A. Wolszczan, Alonso A., Benz W., C. R. Gelino, Cannon A. J., de Medeiros J. R., G. Maciejewski, G. Nowak, Hog E., L. W. Ramsey, M. Konacki, M. Shao, M. Shetrone, Stumpff P.   +14 more
core   +2 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression

Frontiers in Cell and Developmental Biology, 2018
Metastasis is the leading cause of cancer death, tumor progression proceeding through emigration from the primary tumor, gaining access to the circulation, leaving the circulation, settling in distant organs and growing in the foreign environment.
Zhe Wang, Kun Zhao, Thilo Hackert, Margot Zöller   +3 more
doaj   +1 more source

Scion on a stock producing siRNAs of potato spindle tuber viroid (PSTVd) attenuates accumulation of the viroid. [PDF]

PLoS ONE, 2013
Plants can attenuate the replication of plant viruses and viroids by RNA silencing induced by virus and viroid infection. In higher plants, silencing signals such as small interfering RNAs (siRNAs) produced by RNA silencing can be transported ...
Atsushi Kasai, Teruo Sano, Takeo Harada
doaj   +1 more source

Span, Cospan, and Other Double Categories [PDF]

, 2012
Given a double category D such that D_0 has pushouts, we characterize oplax/lax adjunctions between D and Cospan(D_0) such that the right adjoint is normal and restricts to the identity on D_0, where Cospan(D_0) denotes the double category on D_0 whose ...
Niefield, Susan
core   +1 more source

A High-Eccentricity Low-Mass Companion to HD 89744

, 2000
HD 89744 is an F7 V star with mass 1.4 M, effective temperature 6166 K, age 2.0 Gy and metallicity [Fe/H]= 0.18. The radial velocity of the star has been monitored with the AFOE spectrograph at the Whipple Observatory since 1996, and evidence has been ...
Allende Prieto C., Baliunas S., Bernacca P. L., Debra A. Fischer, Edvardsson B., Favata F., Gonzalez G., Ng Y. K., Peter Nisenson, Robert W. Noyes, Sylvain G. Korzennik, Timothy M. Brown   +11 more
core   +2 more sources

Stem Cells and Regenerative Medicine in Domestic and Companion Animals: A Multispecies Perspective [PDF]

Reproduction in Domestic Animals, 2014
ContentsSince their original isolation, the majority of the work on embryonic stem cells (ESC) has been carried out in mice. While the mouse is an outstanding model for basic research, it also has considerable limitations for translational work, especially in the area of regenerative medicine.
N N, Gonçalves, C E, Ambrósio, J A, Piedrahita   +2 more
openaire   +2 more sources

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source