Results 111 to 120 of about 56,406 (298)

PERSONALISED MEDICINE WITH COMPANION DIAGNOSTICS: THE INTERCEPT OF MEDICINES AND MEDICAL DEVICES IN THE REGULATORY LANDSCAPE

European Medical Journal Innovations, 2017
Personalised medicine, with the aid of companion diagnostics, is a burgeoning field. The potential benefits of personalised medicine with regard to improved patient outcomes and reducing healthcare burden are recognised, but there remains obstacles that ...
Amanda Craig
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Imaging-guided Companion Theranostics: Ushering in A New Era of Personalized Cancer Care

Nano Biomedicine and Engineering
Tumor heterogeneity has increasingly underscored the urgent need for personalized medicine, prompting the Food and Drug Administration (FDA) to approve in vitro companion diagnostics (CDx) for patient stratification. This evolving landscape has gradually
Meng Li, Yumeng Wu, Jing Lin
doaj   +1 more source

Astroserver - Research Services in the Stellar Webshop

, 2017
A quick look at research and development in astronomy shows that we live in exciting times. Exoplanetary systems, supernovae, and merging binary black holes were far out of reach for observers two decades ago and now such phenomena are recorded routinely.
Nemeth, Peter
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Targeted therapies with companion diagnostics in the management of breast cancer: current perspectives

Pharmacogenomics and Personalized Medicine, 2016
Meagan B Myers Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA Abstract: Breast cancer is a multifaceted disease exhibiting both intertumoral and intratumoral ...
Myers MB
doaj  

Emerging insights into intravital imaging, unraveling its role in cancer immunotherapy

Cancer Immunology, Immunotherapy
Cancer immunotherapy has attracted great attention as a potential therapeutic approach for advanced malignancies due to its promising survival benefits.
Minfeng Yang, Shiqiang Hou, Yao Chen, Hongzhao Chen, Minjie Chu, Song-Bai Liu   +5 more
doaj   +1 more source

Navigating the Rapids : The Development of NGS-based Clinical Trial Assays and Companion Diagnostics

Frontiers in Oncology, 2014
Over the past decade, next generation sequencing (NGS) technology has experienced meteoric growth in the aspects of platform, technology and supporting bioinformatics development allowing its widespread and rapid uptake in research settings.
Saumya ePant, Russell eWeiner, Matthew John Marton   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Demography of SDSS early-type galaxies from the perspective of radial color gradients

, 2010
We have investigated the radial g-r color gradients of early-type galaxies in the Sloan Digital Sky Survey (SDSS) DR6 in the redshift range 0 ...
Adelman-McCarthy, Bartholomew, Bender, Bernardi, Bernardi, Blanton, Bohlin, Bower, Bower, Calzetti, Ciotti, de Vaucouleurs, Donas, Ellis, Elmegreen, Ferreras, Ferreras, Ferreras, Hyewon Suh, Hyunjin Jeong, Ignacio Ferreras, Kannappan, Kaviraj, Kevin Schawinski, Kewley, Kewley, Kimm, Kodama, Kormendy, Kyuseok Oh, La Barbera, Larson, Larson, Larson, Lauer, Marcum, Menanteau, Norton, Park, Peletier, Poggianti, Rest, Salim, Schawinski, Schlegel, Stanford, Stoughton, Strauss, Sukyoung K. Yi, Tremonti, van Dokkum, Wu, Wyder, Yang, Yi, Yi, Yoon, York   +57 more
core   +1 more source