Results 31 to 40 of about 750,346 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of Real-World On-Label Treatment Persistence in Patients with Psoriatic Arthritis Receiving Guselkumab Versus Subcutaneous Tumor Necrosis Factor Inhibitors

Drugs - Real World Outcomes
Background Treatment persistence among patients with psoriatic arthritis (PsA) is essential for achieving optimal treatment outcomes. Guselkumab, a fully human interleukin-23p19-subunit inhibitor, was approved by the United States (US) Food and Drug ...
Jessica A. Walsh, Iris Lin, Ruizhi Zhao, Natalie J. Shiff, Laura Morrison, Bruno Emond, Louise H. Yu, Samuel Schwartzbein, Patrick Lefebvre, Dominic Pilon, Soumya D. Chakravarty, Philip Mease   +11 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Enrichment of Trace Selenium in Water Based on Metal−Organic Framework Materials and Reversed−Phase Ultra−High−Performance Liquid Chromatography−Diode Array Determination

Separations
A method for the determination of trace selenium in water enriched by metal–organic−framework material (MIL−125−NH2) and reversed−phase ultra−high−performance liquid chromatography−diode array detection (UPLC−DAD) was established.
Hanqing Cai, Hongmei Guo, Hanlu Jing, Pingping Wen, Qiuying Wu, Yang Li, Zhirong Suo, Jian Zhang   +7 more
doaj   +1 more source

Ex-vessel neutron dosimetry results in the extended beltline region [PDF]

EPJ Web of Conferences
Embrittlement of the pressure vessel has been a long-standing concern for pressurized water reactors. Historically, the beltline region of the pressure vessel, or the region of the pressure vessel located opposite the active fuel, has been the primary ...
Hayes Eugene T.
doaj   +1 more source

Leg Length Discrepancy and Nonspecific Low Back Pain: 3-D Stereophotogrammetric Quantitative Posture Evaluation Confirms Positive Effects of Customized Heel-Lift Orthotics

Frontiers in Bioengineering and Biotechnology, 2022
Background: The literature reports evidence of leg length discrepancy (LLD) associated with musculoskeletal disorders, alterations in spinopelvic alignment, and body posture, leading to low back pain and lumbar scoliosis.
Moreno D’Amico, Moreno D’Amico, Edyta Kinel, Piero Roncoletta   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Beyond Tailpipe Emissions: Life Cycle Assessment Unravels Battery’s Carbon Footprint in Electric Vehicles

World Electric Vehicle Journal
While electric vehicles (EVs) offer lower life cycle greenhouse gas emissions in some regions, the concern over the greenhouse gas emissions generated during battery production is often debated.
Sharath K. Ankathi, Jessey Bouchard, Xin He   +2 more
doaj   +1 more source

Health Care Burden of Bronchopulmonary Dysplasia Among Extremely Preterm Infants

Frontiers in Pediatrics, 2019
Background: Infants born extremely preterm are at high risk of developing bronchopulmonary dysplasia (BPD). This study aimed to assess the incremental health care burden of BPD and associated comorbidities among extremely preterm infants in the United ...
Meredith E. Mowitz, Rajeev Ayyagari, Wei Gao, Jing Zhao, Alexandra Mangili, Sujata P. Sarda   +5 more
doaj   +1 more source

ABC ANALYSIS in a CLOTHING COMPANY

Annals of the University of Oradea: Fascicle of Textiles, Leatherwork, 2017
In today’s conditions, clothing companies should cope with the rivalry in order to survive in the sector. Shortening the process times, decreasing the costs, improving the quality are some of the ways of overcoming the competition. ABC analysis, which is also named pareto method or 80/20 rule, is a method that can be used for solving many problems in ...
KARABAY, GÜLSEREN, tunca, burcu, kurumer, gulseren   +2 more
openaire   +3 more sources