Results 151 to 160 of about 1,657,556 (272)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Obamacare to Come: Seven Bad Ideas for Health Care Reform [PDF]

, 2009
President Obama has made it clear that reforming the American health care system will be one of his top priorities. In response, congressional leaders have promised to introduce legislation by this summer, and they hope for an initial vote in the Senate ...
Michael D. Tanner
core  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

An evaluation of stakeholder engagement in comparative effectiveness research: lessons learned from SWOG S1415CD. [PDF]

J Comp Eff Res, 2022
Bell-Brown A, Watabayashi K, Kreizenbeck K, Ramsey SD, Bansal A, Barlow WE, Lyman GH, Hershman DL, Mercurio AM, Segarra-Vazquez B, Kurttila F, Myers JS, Golenski JD, Johnson J, Erwin RL, Walia G, Crawford J, Sullivan SD.   +17 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A Statistical Framework to Detect and Quantify Operator-Learning Curves in Medical Device Safety Evaluation

Medical Devices: Evidence and Research
Henry C Ssemaganda,1 Sharon E Davis,2 Usha S Govindarajulu,3 Jejo D Koola,4 Jialin Mao,5 Dax Marek Westerman,6 Amy M Perkins,6 Theodore Speroff,7 Craig R Ramsay,8 Art Sedrakyan,5 Lucila Ohno-Machado,9 Michael E Matheny,10,11,* Frederic S Resnic1 ...
Ssemaganda HC, Davis SE, Govindarajulu US, Koola JD, Mao J, Westerman DM, Perkins AM, Speroff T, Ramsay CR, Sedrakyan A, Ohno-Machado L, Matheny ME, Resnic FS   +12 more
doaj  

Comparative-effectiveness research of COVID-19 treatment: a rapid scoping review. [PDF]

BMJ Open, 2022
Pham B, Rios P, Radhakrishnan A, Darvesh N, Antony J, Williams C, Ramkissoon N, Cormack GV, Grossman MR, Kampman M, Patel M, Yazdi F, Robson R, Ghassemi M, Macdonald E, Warren R, Muller MP, Straus SE, Tricco AC.   +18 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Impact of Integrating Machine Learning in Comparative Effectiveness Research of Oral Anticoagulants in Patients with Atrial Fibrillation. [PDF]

Int J Environ Res Public Health, 2022
Han S, Suh HS.
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source