Results 131 to 140 of about 3,218,020 (355)

Paleo‐metagenomics of North American fossil packrat middens: Past biodiversity revealed by ancient DNA

Ecology and Evolution, 2020
Fossil rodent middens are powerful tools in paleoecology. In arid parts of western North America, packrat (Neotoma spp.) middens preserve plant and animal remains for tens of thousands of years.
Grace Moore, Michael Tessler, Seth W. Cunningham, Julio Betancourt, Robert Harbert   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Comparative genomics of lactic acid bacteria reveals a niche-specific gene set

, 2009
peer-reviewedBackground: The recently sequenced genome of Lactobacillus helveticus DPC4571 1 revealed a dairy organism with significant homology (75% of genes are homologous) to a probiotic bacteria Lb. acidophilus NCFM 2. This led us to hypothesise that
O\u27Callaghan, John, Callanan, Michael J., Fitzgerald, Gerald F, Gerald F Fitzgerald, Sangrador-Vegas, Amaia, Kaleta Pawel, O'Callaghan John, O'Sullivan, Orla, Fitzgerald Gerald F, Callanan Michael, O\u27Sullivan, Orla, Ross, R. Paul, Fitzgerald, Gerald F., Michael Callanan, O'Callaghan, John, Tom Beresford, Orla O'Sullivan, O'Sullivan Orla, Beresford, Thomas P., John O'Callaghan, Ross R Paul, Kaleta, Pawel, McAuliffe Olivia, Beresford, Tom, Olivia McAuliffe, Lydia Slattery, Amaia Sangrador-Vegas, McAuliffe, Olivia, Slattery Lydia, Pawel Kaleta, R Paul Ross, Slattery, Lydia, Beresford Tom, Ross, R Paul, Callanan, Michael, Sangrador-Vegas Amaia   +35 more
core   +1 more source

Population genetic structure and habitat connectivity for jaguar (Panthera onca) conservation in Central Belize

BMC Genetics, 2019
Background Connectivity among jaguar (Panthera onca) populations will ensure natural gene flow and the long-term survival of the species throughout its range.
Angelica Menchaca, Natalia A. Rossi, Jeremy Froidevaux, Isabela Dias-Freedman, Anthony Caragiulo, Claudia Wultsch, Bart Harmsen, Rebecca Foster, J. Antonio de la Torre, Rodrigo A. Medellin, Salisa Rabinowitz, George Amato   +11 more
doaj   +1 more source

Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

BMC Evolutionary Biology, 2020
Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly expressed in neurons (1–2% in ...
Muhammad Saqib Nawaz, Razia Asghar, Nashaiman Pervaiz, Shahid Ali, Irfan Hussain, Peiqi Xing, Yiming Bao, Amir Ali Abbasi   +7 more
doaj   +1 more source

Comparative genomics of the tardigrades Hypsibius dujardini and Ramazzottius varieornatus

bioRxiv, 2017
Tardigrada, a phylum of meiofaunal organisms, have been at the center of discussions of the evolution of Metazoa, the biology of survival in extreme environments, and the role of horizontal gene transfer in animal evolution.
Yuki Yoshida, Georgios D. Koutsovoulos, D. Laetsch, L. Stevens, Sujai Kumar, D. Horikawa, Kyoko Ishino, Shiori Komine, Takekazu Kunieda, M. Tomita, M. Blaxter, K. Arakawa   +11 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Comparative genomics web resources.

, 2013
Comparative genomics web resources.
Rose Oughtred (5621), Charles Lu (33589), Kara Dolinski (5614), Samuel V. Angiuoli (33591), Fan Kang (33590), Sven Heinicke (33588), David Botstein (197), Owen White (189), Michael S. Livstone (14161)   +8 more
core   +1 more source

The animal in the genome: comparative genomics and evolution [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
Comparisons between completely sequenced metazoan genomes have generally emphasized how similar their encoded protein content is, even when the comparison is between phyla. Given the manifest differences between phyla and, in particular, intuitive notions that some animals are more complex than others, this creates something of a paradox ...
openaire   +3 more sources

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

BMC Evolutionary Biology, 2019
Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi   +5 more
doaj   +1 more source