Results 121 to 130 of about 3,218,020 (355)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RegPredict: an integrated system for regulon inference in prokaryotes by comparative genomics approach [PDF]

, 2010
RegPredict web server is designed to provide comparative genomics tools for reconstruction and analysis of microbial regulons using comparative genomics approach.
I. Dubchak, Novichkova, Elena S., P. S. Novichkov, Gelfand, Mikhail S., A. P. Arkin, E. S. Novichkova, Novichkov, Pavel S., E. D. Stavrovskaya, Stavrovskaya, Elena D., D. A. Rodionov, Kazakov, Alexey E., Dubchak, Inna, Arkin, Adam P., Mironov, Andrey A., A. E. Kazakov, M. S. Gelfand, A. A. Mironov, Rodionov, Dmitry A.   +17 more
core   +1 more source

Comparative genomics of Meloidogyne haplanaria [PDF]

, 2020
Data related to the MSC thesis 'Comparative genomics of Meloidogyne haplanaria'
Winter, Michael Robert, Winter, Mike
core   +1 more source

Adaptations to High Salt in a Halophilic Protist: Differential Expression and Gene Acquisitions through Duplications and Gene Transfers

Frontiers in Microbiology, 2017
The capacity of halophiles to thrive in extreme hypersaline habitats derives partly from the tight regulation of ion homeostasis, the salt-dependent adjustment of plasma membrane fluidity, and the increased capability to manage oxidative stress ...
Tommy Harding, Andrew J. Roger, Alastair G. B. Simpson   +2 more
doaj   +1 more source

Comparative genomics reveals phylogenetic distribution patterns of secondary metabolites in Amycolatopsis species

BMC Genomics, 2018
Genome mining tools have enabled us to predict biosynthetic gene clusters that might encode compounds with valuable functions for industrial and medical applications. With the continuously increasing number of genomes sequenced, we are confronted with an
Martina Adamek, Mohammad Alanjary, Helena Sales-Ortells, M. Goodfellow, A. Bull, Anika Winkler, D. Wibberg, J. Kalinowski, N. Ziemert   +8 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Comparative genomics on gene and single nucleotide level

, 2013
Blom J. Comparative genomics on gene and single nucleotide level.
Blom, Jochen
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cloud computing for comparative genomics [PDF]

, 2010
Background Large comparative genomics studies and tools are becoming increasingly more compute-expensive as the number of available genome sequences continues to rise.
Vincent A Fusaro, Fusaro Vincent A, Prasad Patil, Wall Dennis P, Patil, Prasad, Kudtarkar, Parul, Tonellato, Peter, Dennis P Wall, Peter J Tonellato, Wall, Dennis Paul, Pivovarov, Rimma, Rimma Pivovarov, Patil Prasad, Pivovarov Rimma, Kudtarkar Parul, Parul Kudtarkar, Tonellato Peter J, Fusaro, Vincent Alfred   +17 more
core   +1 more source

Whole-genome sequence, SNP chips and pedigree structure: building demographic profiles in domestic dog breeds to optimize genetic-trait mapping

Disease Models & Mechanisms, 2016
In the decade following publication of the draft genome sequence of the domestic dog, extraordinary advances with application to several fields have been credited to the canine genetic system.
Dayna L. Dreger, Maud Rimbault, Brian W. Davis, Adrienne Bhatnagar, Heidi G. Parker, Elaine A. Ostrander   +5 more
doaj   +1 more source