Results 101 to 110 of about 3,218,020 (355)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Unlocking the Barley Genome by Chromosomal and Comparative Genomics   [PDF]

The Plant Cell, 2011
AbstractWe used a novel approach that incorporated chromosome sorting, next-generation sequencing, array hybridization, and systematic exploitation of conserved synteny with model grasses to assign ~86% of the estimated ~32,000 barley (Hordeum vulgare) genes to individual chromosome arms.
Mayer, Klaus F. X., Martis, Mihaela, Hedley, Pete E., Simkova, Hana, Liu, Hui, Morris, Jenny A., Steuernagel, Burkhard, Taudien, Stefan, Roessner, Stephan, Gundlach, Heidrun, Kubalakova, Marie, Suchankova, Pavla, Murat, Florent, Felder, Marius, Nussbaumer, Thomas, Graner, Andreas, Salse, Jerome, Endo, Takashi, Sakai, Hiroaki, Tanaka, Tsuyoshi, Itoh, Takeshi, Sato, Kazuhiro, Platzer, Matthias, Matsumoto, Takashi, Scholz, Uwe, Dolezel, Jaroslav, Waugh, Robbie, Stein, Nils   +27 more
openaire   +4 more sources

The Cyclic AMP Receptor Protein, Crp, Is Required for the Decolorization of Acid Yellow 36 in Shewanella putrefaciens CN32

Frontiers in Microbiology, 2020
Shewanella shows good application potentials in the decolorization and detoxification of azo dye wastewater. However, the molecular mechanism of decolorization is still lacking. In this study, it was found that Shewanella putrefaciens CN32 exhibited good
Weijie Liu, Ying Chen, Xuge Zhou, Jiawen Liu, Jingrong Zhu, Shiwei Wang, Cong Liu, Di Sun   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

EDGAR: a software framework for the comparative analysis of prokaryotic genomes

, 2009
Blom J, Albaum S, Doppmeier D, et al. EDGAR: a software framework for the comparative analysis of prokaryotic genomes. BMC Bioinformatics. 2009;10(1): 154.Background:The introduction of next generation sequencing approaches has caused a rapid increase in
Blom, Jochen, Albaum, Stefan ; https://orcid.org/, Jochen Blom, Martha Zakrzewski, Goesmann, Alexander ; https://orcid.org/, Alfred Puhler, Pühler, Alfred ; https://orcid.org/, Zakrzewski, Martha, Doppmeier, Daniel, Vorhölter, Frank-Jörg, Stefan P Albaum, Daniel Doppmeier, Frank-Jorg Vorholter, Alexander Goesmann   +13 more
core   +1 more source

JGI Fungal Genomics Program [PDF]

, 2011
Genomes of energy and environment fungi are in focus of the Fungal Genomic Program at the US Department of Energy Joint Genome Institute (JGI). Its key project, the Genomics Encyclopedia of Fungi, targets fungi related to plant health (symbionts ...
Igor V. Grigoriev, Grigoriev, Igor V.
core   +1 more source

Comparative genomics and the nature of placozoan species

PLoS Biology, 2018
Placozoans are a phylum of nonbilaterian marine animals currently represented by a single described species, Trichoplax adhaerens, Schulze 1883. Placozoans arguably show the simplest animal morphology, which is identical among isolates collected ...
M. Eitel, W. Francis, F. Varoqueaux, J. Daraspe, Hans-Jürgen Osigus, S. Krebs, S. Vargas, H. Blum, G. Williams, B. Schierwater, G. Wörheide   +10 more
semanticscholar   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on noncoding sequences

, 2005
The non-coding portion of human genome is punctuated by a large number of multispecies conserved sequence (MCS) elements with largely unknown function.
Uberto Pozzoli, N. Bresolin, U. Pozzoli, G.P. Comi, R. Cagliani, Manuela Sironi, Giacomo P. Comi, Giorgia Menozzi, Rachele Cagliani, G. Menozzi, Nereo Bresolin, M. Sironi   +11 more
core   +1 more source

Comparative genomics and bioenergetics

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001
Bacterial and archaeal complete genome sequences have been obtained from a wide range of evolutionary lines, which allows some general conclusions about the phylogenetic distribution and evolution of bioenergetic pathways to be drawn. In particular, I searched in the complete genomes for key enzymes involved in aerobic and anaerobic respiratory ...
openaire   +2 more sources