Results 91 to 100 of about 431,462 (299)

Virus-induced gene complementation reveals a transcription factor network in modulation of tomato fruit ripening [PDF]

, 2012
Plant virus technology, in particular virus-induced gene silencing, is a widely used reverse- and forward-genetics tool in plant functional genomics. However the potential of virus technology to express genes to induce phenotypes or to complement mutants
Fan, Zaifeng, Gallusci, Philippe, Giovannoni, James J., Hong, Yiguo, Jackson, Stephen D., Jin, Mingfei, Lai, Tongfei, Liu, Yule, Qin, Cheng, Rolin, Dominique, Shi, Nongnong, Wang, Huizhong, Wu, Zirong, Zhang, Hang, Zhong, Silin, Zhou, Tao   +15 more
core   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Population genetic structure and habitat connectivity for jaguar (Panthera onca) conservation in Central Belize

BMC Genetics, 2019
Background Connectivity among jaguar (Panthera onca) populations will ensure natural gene flow and the long-term survival of the species throughout its range.
Angelica Menchaca, Natalia A. Rossi, Jeremy Froidevaux, Isabela Dias-Freedman, Anthony Caragiulo, Claudia Wultsch, Bart Harmsen, Rebecca Foster, J. Antonio de la Torre, Rodrigo A. Medellin, Salisa Rabinowitz, George Amato   +11 more
doaj   +1 more source

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

BMC Evolutionary Biology, 2019
Background Frizzled family members belong to G-protein coupled receptors and encode proteins accountable for cell signal transduction, cell proliferation and cell death. Members of Frizzled receptor family are considered to have critical roles in causing
Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi   +5 more
doaj   +1 more source

Comparative Genomics of a Parthenogenesis-Inducing Wolbachia Symbiont. [PDF]

, 2016
Wolbachia is an intracellular symbiont of invertebrates responsible for inducing a wide variety of phenotypes in its host. These host-Wolbachia relationships span the continuum from reproductive parasitism to obligate mutualism, and provide a unique ...
Lindsey, Amelia RI, Richards, Stephen, Stouthamer, Richard, Werren, John H   +3 more
core   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Seqrutinator: scrutiny of large protein superfamily sequence datasets for the identification and elimination of non-functional homologues

Genome Biology
Seqrutinator is an objective, flexible pipeline that removes sequences with sequencing and/or gene model errors and sequences from pseudogenes from complex, eukaryotic protein superfamilies.
Agustín Amalfitano, Nicolás Stocchi, Hugo Marcelo Atencio, Fernando Villarreal, Arjen ten Have   +4 more
doaj   +1 more source

A web-based, patient driven registry for Angelman syndrome: the global Angelman syndrome registry

Orphanet Journal of Rare Diseases, 2017
Angelman syndrome (AS) is a rare neurodevelopmental disorder that is characterised by severe global developmental delays, ataxia, loss of speech, epilepsy, sleep disorders, and a happy disposition.
Kathryn R. Napier, Megan Tones, Chloe Simons, Helen Heussler, Adam A. Hunter, Meagan Cross, Matthew I. Bellgard   +6 more
doaj   +1 more source

Chromosome-level assembly of the horseshoe crab genome provides insights into its genome evolution

Nature Communications, 2020
Horseshoe crabs have been morphologically stable across evolutionary time. Here, the authors generate a chromosome-level assembly for the mangrove horseshoe crab, with implications for innate immunity, and challenging assumptions about the role of genome
Prashant Shingate, Vydianathan Ravi, Aravind Prasad, Boon-Hui Tay, Kritika M. Garg, Balaji Chattopadhyay, Laura-Marie Yap, Frank E. Rheindt, Byrappa Venkatesh   +8 more
doaj   +1 more source