Results 71 to 80 of about 427,581 (278)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Gene Loss and Horizontal Gene Transfer Contributed to the Genome Evolution of the Extreme Acidophile “Ferrovum” [PDF]

, 2016
Indexación: Web of Science. Scopus.Acid mine drainage (AMD), associated with active and abandoned mining sites, is a habitat for acidophilic microorganisms that gain energy from the oxidation of reduced sulfur compounds and ferrous iron and that thrive ...
Daniel, Rolf, González, Carolina, Holmes, David S., Mühling, Martin, Poehlein, Anja, Schlömann, Michael, Tischler, Judith S., Ullrich, Sophie R.   +7 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

GreenPhyl : Phylogenomic resources for comparative and functional genomics [PDF]

, 2010
With the increasing number of plant genomes being sequenced, a major objective is to transfer accurate annotation from characterized sequences to uncharacterized sequences.
Aluome, Christelle, Conte, Matthieu, Droc, Gaëtan, Guignon, Valentin, Lanau, Nadège, Laporte, Marie-Angélique, Perin, Christophe, Rouard, Mathieu, Sempere, Guilhem   +8 more
core  

Development of ListeriaBase and comparative analysis of Listeria monocytogenes [PDF]

, 2015
Background: Listeria consists of both pathogenic and non-pathogenic species. Reports of similarities between the genomic content between some pathogenic and non-pathogenic species necessitates the investigation of these species at the genomic level to ...
Ang, Mia Yang, Choo, Siew Woh, Dutta, Avirup, Heydari, Hamed, Mutha, Naresh VR, Siow, Cheuk Chuen, Tan, Mui Fern, Tan, Shi Yang, Wee, Wei Yee, Wong, Guat Jah   +9 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist

Nature Communications, 2021
The mechanisms for replicating and segregating DNA are highly conserved across eukaryotes. A comparative genomic analysis of a free-living protist finds a surprising lack of protein complexes involved in these processes, suggesting that the organism uses
Dayana E. Salas-Leiva, Eelco C. Tromer, Bruce A. Curtis, Jon Jerlström-Hultqvist, Martin Kolisko, Zhenzhen Yi, Joan S. Salas-Leiva, Lucie Gallot-Lavallée, Shelby K. Williams, Geert J. P. L. Kops, John M. Archibald, Alastair G. B. Simpson, Andrew J. Roger   +12 more
doaj   +1 more source

Towards a bioinformatics platform for the Musa research community : [Abstract W076] [PDF]

, 2010
Current experiments in genomics produce a large amount of data that needs to be organized into databases and broadly accessible. Like other species, the Musa genomics community would benefit from centralized and innovative ways to study its genome.
Argout, Xavier, Bocs, Stéphanie, Conte, Matthieu, Droc, Gaëtan, Guignon, Valentin, Hamelin, Chantal, Rouard, Mathieu, Roux, Nicolas, Ruiz, Manuel   +8 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Adaptations to High Salt in a Halophilic Protist: Differential Expression and Gene Acquisitions through Duplications and Gene Transfers

Frontiers in Microbiology, 2017
The capacity of halophiles to thrive in extreme hypersaline habitats derives partly from the tight regulation of ion homeostasis, the salt-dependent adjustment of plasma membrane fluidity, and the increased capability to manage oxidative stress ...
Tommy Harding, Andrew J. Roger, Alastair G. B. Simpson   +2 more
doaj   +1 more source