Results 21 to 30 of about 57,312 (259)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Aspect in the English language: a comparative analysis of form and meaning in traditional descriptive grammars [PDF]

open access: yesDELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2019
Aspect in the English language has been described through different categories and terminologies, which might lead teachers and students into some misunderstandings.
Adriana Lessa, Maria das Graças Salgado
doaj   +1 more source

Issues in the grammar of Turkish comparatives

open access: yesDilbilim Araştırmaları Dergisi, 2023
The paper investigates several issues in the syntax/semantics of comparison constructions in Turkish. We first show that although comparison constructions use nominalized constituents in marking the standard of comparison, they involve rich clausal structure under this nominalization.
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

A Morphosyntactic Analysis of Verbal Structure in the Laki Dialect and Its Relation to the Persian Verb System [In Persian] [PDF]

open access: yesزبان کاوی کاربردی
Adopting a descriptive‑analytical approach, this study examines the morphosyntactic structure of verbs in the Laki dialect and explores its relationship with the verbal system of standard Persian.
Ali Bazvand
doaj  

Pembelajaran Kooperatif Tipe Think-Pair-Share dan Pembelajaran Berbasis Proyek dalam Meningkatkan Pemahaman Tata Bahasa Arab

open access: yesUkazh
Learning Arabic grammar often presents a significant challenge for students, necessitating innovative strategies to enhance comprehension. This research aims to analyze the comparative impact and simultaneous contribution of the Think-Pair-Share ...
Ali Rohmat, Zaenal Abidin
doaj   +1 more source

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