Results 241 to 250 of about 9,854,366 (294)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Concretizing the abstract: embodied learning as a pedagogical strategy for teaching measurement and evaluation. [PDF]

BMC Med Educ
Tutal Ö.
europepmc   +1 more source

Comparison of Cumulative Dissipated Energy Between Two Phacoemulsification Systems Using a Modified Flip-and-Chop Technique With Multidirectional Jerking Movement From a Phacoemulsification Handpiece. [PDF]

Cureus
Chen M, Lin HY, Kang EJ.
europepmc   +1 more source

Fit one model, report one number: how to analyse a training or intervention study. [PDF]

Front Physiol
Schappacher-Tilp G, Tilp M.
europepmc   +1 more source

Beyond the Scalpel: A Cross-Sectional Study of Psychological Well-Being and Quality of Life in Women With a History of Cosmetic Surgery, Surgical Candidates, and a Comparison Group. [PDF]

Health Sci Rep
Fathnezhad-Kazemi A, Zeraati AR.
europepmc   +1 more source

Preoperative versus postoperative single-fraction or fractionated stereotactic radiosurgery for resected brain metastases: a systematic review and network meta-analysis. [PDF]

Front Oncol
Zhao T, Lu S.
europepmc   +1 more source