Results 111 to 120 of about 663,640 (272)

ALS plasma biomarkers reveal neurofilament and pTau correlate with disease onset and progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Abstract Objective We performed a pilot screen to assess the utility of the NULISA™ (Nucleic‐acid‐Linked Immuno‐Sandwich Assay) platform in the identification of amyotrophic lateral sclerosis (ALS) biomarkers. Methods Plasma from 86 individuals (48 ALS, 18 asymptomatic C9orf72 repeat expansion carriers (AsymC9), and 20 healthy controls) was analyzed ...
Eleanor V. Thomas   +10 more
wiley   +1 more source

A strong comparison principle for the $p$-Laplacian [PDF]

open access: hybrid, 2007
Paolo Roselli, Berardino Sciunzi
openalex   +1 more source

Combined Systemic Immunotherapy and Intrathecal Dexamethasone in Febrile Infection Related Epilepsy Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Febrile infection related epilepsy syndrome (FIRES) is a rare presentation of refractory status epilepticus with immune dysregulation as a potential pathologic mechanism. Despite promising results from second‐line immunomodulators, approximately 30% remain refractory to treatment.
Kristen S. Fisher   +5 more
wiley   +1 more source

On the Keldys-Fichera boundary-value problem for degenerate quasilinear elliptic equations

open access: yesElectronic Journal of Differential Equations, 2002
We prove existence and uniqueness theorems for the Keldys-Fichera boundary-value problem using pseudo-monotone operators. The equation studied here is quasilinear, elliptic, and its set of degenerate points may be of non-zero measure.
Zu-Chi Chen, Benjin Xuan
doaj  

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men   +11 more
wiley   +1 more source

Nonuniqueness of solutions of initial-value problems for parabolic p-Laplacian

open access: yesElectronic Journal of Differential Equations, 2015
We construct a positive solution to a quasilinear parabolic problem in a bounded spatial domain with the p-Laplacian and a nonsmooth reaction function. We obtain nonuniqueness for zero initial data.
Jiri Benedikt   +4 more
doaj  

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner   +12 more
wiley   +1 more source

“It's Just Good Science”: A Qualitative Study Exploring Equity, Diversity, and Inclusion in Canadian Arthritis Research

open access: yesArthritis Care &Research, EarlyView.
Objective Despite knowledge that health outcomes vary according to patient characteristics, identity, and geography, including underrepresented populations in arthritis research remains a challenge. We conducted interviews to explore how researchers in arthritis have used equity, diversity, and inclusion (EDI) principles to inform their research ...
Megan M. Thomas   +8 more
wiley   +1 more source

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