Results 111 to 120 of about 2,703,249 (309)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

open access: yesAdvanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li   +10 more
wiley   +1 more source

Behavior of the maximal solution of the Cauchy problem for some nonlinear pseudoparabolic equation as $|x|oinfty$

open access: yesElectronic Journal of Differential Equations, 2012
We prove a comparison principle for solutions of the Cauchy problem of the nonlinear pseudoparabolic equation $u_t=Delta u_t+ Deltavarphi(u) +h(t,u)$ with nonnegative bounded initial data.
Tatiana Kavitova
doaj  

N-functions and the weak comparison principle

open access: yesJournal of Differential Equations, 1980
A(t) is called an N-function if A(t) = si 01(s) ds for 0 0 for t > 0, a(0) = 0, and Km,,, a(t) = +ox. (See [l, p. 2281 or [4, p. 61.) In this paper, we shall deal only with N-functions A which are twice differentiable on (0, 03) with A”(t) > 0 for t > 0; so, in particular, dA/dt = A’ = a: is strictly increasing and continuous for 0 < t < 00. Defining
openaire   +2 more sources

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

open access: yesAdvanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran   +5 more
wiley   +1 more source

Numerical Studies of Influencing Factors on the Homogeneity of the Powder Mixture during the Powder Spreading Process of Powder Bed Fusion–Laser Beam/Metal

open access: yesAdvanced Engineering Materials, EarlyView.
AISI 304L stainless steel powder is mixed with silicon nitride (Si3N4) powder and processed by PBF‐LB/M, allowing partial retention of Si3N4. The numerical approach effectively predicts the Si3N4 powder homogeneity and N content distribution on the powder bed. Recent studies have focused on the alloying of nitrogen (N) in high‐alloy stainless steels by
Yuanbin Deng   +7 more
wiley   +1 more source

Existence and uniqueness for a dislocation model with short-range interactions and varying stress field

open access: yesElectronic Journal of Differential Equations, 2015
In this article, we consider a coupled singular parabolic system, describing the dynamics of dislocation densities in a bounded domain. The model takes into consideration the short-range interactions between dislocations, which causes the singularity ...
Hassan Ibrahim
doaj  

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