Results 121 to 130 of about 5,620,148 (306)
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Electronic Journal of Differential Equations, 2015 In this article, we consider a coupled singular parabolic system, describing the dynamics of dislocation densities in a bounded domain. The model takes into consideration the short-range interactions between dislocations, which causes the singularity ...
Hassan Ibrahim
doaj
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
A comparison principle for terminal value problems in ordinary differential equations
, 1972 A comparison principle for a terminal value problem of an ordinary differential equation is formulated. Basic related topics such as the existence of maximal and minimal solutions of terminal value problems are investigated.
Thomas G. Hallam
core +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Imperfect Commitment and the Revelation Principle [PDF]
This paper extends the revelation principle to environments in which the mechanism designer cannot fully commit to the outcome induced by the mechanism.
Helmut Bester, Roland Strausz
core
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen +5 more
wiley +1 more source
Nonuniqueness of solutions of initial-value problems for parabolic p-Laplacian
Electronic Journal of Differential Equations, 2015 We construct a positive solution to a quasilinear parabolic problem in a bounded spatial domain with the p-Laplacian and a nonsmooth reaction function. We obtain nonuniqueness for zero initial data.
Jiri Benedikt +4 more
doaj
On the comparison principle in the calculus of variations
Arkiv för Matematik, 1983 On etudie des integrales variationnelles de la forme I(u,D)=∫ D F(x,⊇u(x))dx,DCG.
openaire +3 more sources