Results 51 to 60 of about 44,422 (248)

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

open access: yesAdvanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin   +12 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Smart System to Coordination of the Available Response Resources in an Oil Spill Leakage [PDF]

open access: yesTransNav, 2019
A smart solution for assessing the consequences of pollution on the coast, on flora and fauna but also by accounting for the total costs of the equipment used in the response to pollution is a system for assessing, coordinating and simulating the risk ...
Mariana Panaitescu   +1 more
doaj   +1 more source

Vibration and noise minimisation in living and working ship compartments [PDF]

open access: yesPolish Maritime Research, 2009
The article discusses the problem of minimisation of the noise emitted by mechanical devices installed on a ship to its living and working compartments. Basic features of the abovementioned mechanical systems are defined taking into account frequencies generated by them.
openaire   +1 more source

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

open access: yesAdvanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang   +8 more
wiley   +1 more source

Stability Analysis of a Bulk Carrier under Damage Scenarios during the Loading of Polymetallic Nodules in the Clarion–Clipperton Zone [PDF]

open access: yesTransNav
A potential consequence of loading polymetallic nodules (PMNs) in a marine environment is liquefaction. During loading operations in the Clarion–Clipperton Zone (CCZ), the ship is exposed to cyclic rolling and pitching, which increases the risk of cargo ...
Pawel Kacprzak
doaj   +1 more source

Safety of Sodium‐Ion Batteries: Evaluation and Perspective from Component Materials to Cells, Modules, and Packs

open access: yesAdvanced Energy Materials, EarlyView.
This review provides a bottom‐up evaluation of sodium‐ion battery safety, linking material degradation mechanisms, cell engineering parameters, and module/pack assembly. It emphasizes that understanding intrinsic material stability and establishing coordinated engineering control across hierarchical levels are vital for preventing degradation coupling ...
Won‐Gwang Lim   +5 more
wiley   +1 more source

Explosion Characteristics of Hydrogen Gas in Varying Ship Ventilation Tunnel Geometries: An Experimental Study

open access: yesJournal of Marine Science and Engineering, 2022
Hydrogen is widely regarded as a key element of prospective energy solutions for alleviating environmental emission problems. However, hydrogen is classified as a high-risk gas because of its wide explosive range, high overpressure, low ignition energy ...
Soung Woo Park   +2 more
doaj   +1 more source

Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]

open access: yes, 2009
Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi   +5 more
core   +2 more sources

Hematoma Interleukin‐1 Receptor Antagonist Concentrations Predict Long‐Term Outcome in Acute Human Intracerebral Hemorrhage

open access: yesAnnals of Neurology, EarlyView.
Objectives The interleukin (IL)‐1, IL‐6, and C‐reactive protein (CRP) pathway is central to the immune response after intracerebral hemorrhage (ICH). We tested for associations between hematoma and plasma cytokine concentrations and patient outcomes in Minimally Invasive Surgery Plus Rt‐PA for ICH Evacuation Phase III (MISTIE III) participants ...
Adrian R. Parry‐Jones   +54 more
wiley   +1 more source

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