Results 211 to 220 of about 821,290 (231)

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

Double Heterozygous CDAN1 Variants of Uncertain Significance Associated With a Phenotype Consistent With Congenital Dyserythropoietic Anemia Type 1. [PDF]

Case Rep Hematol
Zablonski KG, Lachant NA, Perkins A, Archibald WJ.   +3 more
europepmc   +1 more source

Predicting the evolutionary and structural compensation in Tat ARM region across HIV-1 groups using machine learning approach. [PDF]

Sci Rep
Karim R, Arman MS, Kamrul Hasan KM, Hasan Z.   +3 more
europepmc   +1 more source

Naturally occurring mutations in replication proteins of a small RNA virus that alter the number, sizes, and relative abundances of subgenomic RNAs. [PDF]

PLoS Pathog
Perdoncini Carvalho C, Wang D, Han J, Khemsom K, Chen H, Tao Y, Qu F.   +6 more
europepmc   +1 more source

Structural adaptations for enhanced translation kinetics in evolved ribosomes. [PDF]

Nucleic Acids Res
Raskar T, Costello A, Badran AH, Fraser JS.   +3 more
europepmc   +1 more source

Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution

Research in Microbiology, 2004
Compensatory mutations, due to their ability to mask the deleterious effects of another mutation, are important for the adaptation and evolution of most organisms. Resistance to antibiotics, antivirals, antifungals, herbicides and insecticides is usually
Dan Andersson, Sophie Maisnier-Patin
exaly   +2 more sources

Emergence of Resistance in Influenza With Compensatory Mutations

Mathematical Population Studies, 2011
Compensatory mutations are evolutionary responses of influenza viruses resulting in the generation of escape mutants from immune recognition or in the emergence of highly transmissible drug resistant viruses.
Seyed Moghadas
exaly   +2 more sources