Results 241 to 250 of about 29,264,869 (300)

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Leveraging expectation effects to improve outcomes in the context of digital mental health interventions. [PDF]

Internet Interv
Schaeuffele C, Haering S, Kampisiou C, Nestoriuc Y, Wilhelm M, Rief W, Knaevelsrud C.   +6 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Factors Influencing Medication Safety Competence of Nurses According to Clinical Career Stage: A Cross-Sectional Survey. [PDF]

Nurs Health Sci
Jung S, Park J.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Gaming in Medical Education: Promise, Pitfalls, and Practice. [PDF]

Cureus
Singh A, Rajput V.
europepmc   +1 more source

Managers' experiences of collaboration and individual participation in integrated healthcare and social services for adults with complex needs: a focus group study. [PDF]

BMC Health Serv Res
Hjelm M, Plessen V, Andersson A, Harris U.   +3 more
europepmc   +1 more source

A game-based approach to teaching net and wall games in physical education teacher education. [PDF]

Front Sports Act Living
Poncet-Rief M, Rode D.
europepmc   +1 more source

Complex Thoracic Resections in the Minimally Invasive Era: Is Open Surgery Becoming a Lost Skill? [PDF]

J Clin Med
Argento G, Rendina EA, Maurizi G.
europepmc   +1 more source

Embedding laboratory animal welfare- and ethics-related techniques into a comparative medicine laboratory course: an educational reform study. [PDF]

Front Vet Sci
Zhang J, Zhang L, Zhang X, Yao G.
europepmc   +1 more source