Results 41 to 50 of about 992,860 (360)
Scientific Reports, 2017 The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial methylome changes throughout the
Viktorija Kukushkina +12 more
doaj +1 more source
Transport, 2022 This research presents a data-driven Neural Network (NN)-based Virtual Sensor (VS) that estimates vehicles’ Unsprung Mass (UM) vertical velocity in real-time. UM vertical velocity is an input parameter used to control a vehicle’s semi-active suspension.
Paulius Kojis +2 more
doaj +1 more source
Measuring competence?: exploring firm effects in pharmaceutical research
, 1994 Renewed interest in the resource-based theory of the firm has focused attention on the role of heterogeneous organizational ‘competence’ in competition.
R. Henderson, I. Cockburn
semanticscholar +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Rethinking Cultural Competence: Shifting to Cultural Humility
Health Services Insights, 2020 Healthcare and social services providers are deemed culturally competent when they offer culturally appropriate care to the populations they serve. While a review of the literature highlights the limited effectiveness of cultural competence training, its
Helen-Maria Lekas +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Materials Today Advances, 2021 Mechanical metamaterials with variable stiffness recently gained a lot of research interest, as they allow for structures with complex boundary and load conditions.
M. Fleisch +7 more
doaj
Development of Hydraulic Turbodrills for Deep Well Drilling
Applied Sciences, 2021 The article discusses the possibility of improving the design of the turbine of a hydraulic drilling machine for drilling wells in very hard rocks and at considerable depths (5000–12,000 m).
Mikhail V. Dvoynikov +3 more
doaj +1 more source