Results 61 to 70 of about 1,012,717 (310)
F1000ResearchBackground Accurate genome sequences form the basis for genomic surveillance programs, the added value of which was impressively demonstrated during the COVID-19 pandemic by tracing transmission chains, discovering new viral lineages and mutations, and ...
Martin Hölzer +5 more
doaj +1 more source
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
, 2017 In this chapter the theme of competence is addressed in relation to a processual approach to discursive practices. The object “competence” is constructed differently within three main discourses: entity-based, relational, and practice-based.
Silvia Gherardi +3 more
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Future Foreign Language Teachers’ Intercultural Competence [PDF]
, 2013 There is a lack of research regarding the implications for foreign language study and intercultural competence. Scholars suggest that foreign language proficiency plays a role in cultivating intercultural competence, but agree that there is a lack of ...
Baalerud, Andrew
core
A case study of organisational cultural competence in mental healthcare [PDF]
, 2011 Background Ensuring Cultural Competence (CC) in health care is a mechanism to deliver culturally appropriate care and optimise recovery. In policies that promote cultural competence, the training of mental health practitioners is a key component of a ...
Warfa Nasir +8 more
core +2 more sources
Children’s Participation: Questioning Competence and Competencies?
Social Inclusion, 2017 While Article 12 of the Convention on the Rights of the Child has encouraged children’s participation in collective decision-making, the literature is replete with the challenges as well as successes of such participation. One challenge is adults’ perceptions of children’s competence and competencies. These are frequently used as threshold criteria, so
Le borgne, Carine +1 more
openaire +3 more sources
Competence and Competence Development [PDF]
, 2012 What are today's main concepts and theories - and the main stakes - associated with the issue of competences in organizations? Several topics are discussed, including competence issues regarding the evolution of work, professionalization, competence evaluation, competence management, and the competences of adult educators and trainers, as well as ...
+6 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source