Results 41 to 50 of about 1,012,717 (310)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Chemistry Teacher International, 2019 Chemistry teaching and learning bears some subject-specific challenges. For example, explanations and considerations of chemical phenomena drawing on the macroscopic, the sub-microscopic and the representational level.
Lembens Anja +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
BMC Health Services ResearchBackground Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and ...
Ulrika Harris +3 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
BMC Health Services ResearchBackground Adults with long-term mental, cognitive, and physical conditions experience a substantial disease burden and have complex health needs. The co-occurrence of mental health problems, substance use, and social vulnerabilities further underscores ...
Markus Hjelm +3 more
doaj +1 more source
Asymmetric chiral and antichiral mechanical metamaterials with tunable Poisson’s ratio
APL Materials, 2022 Mechanical metamaterials with zero or negative Poisson’s ratio were subject to increasing research interest over the last few years. Their energy absorption capabilities make them suitable for impact and dampening applications, such as personal ...
Mathias Fleisch +6 more
doaj +1 more source
How Do Deep-Learning Framework Versions Affect the Reproducibility of Neural Network Models?
Machine Learning and Knowledge Extraction, 2022 In the last decade, industry’s demand for deep learning (DL) has increased due to its high performance in complex scenarios. Due to the DL method’s complexity, experts and non-experts rely on blackbox software packages such as Tensorflow and Pytorch. The
Mostafa Shahriari +2 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Application of the Wave Based Technique for steady-state semi-infinite sound radiation analysis
Computer Assisted Methods in Engineering and Science, 2022 This paper reports on the development of a novel wave based prediction technique for the steady-state sound radiation analysis of three-dimensional semi-infinite problems.
Jan Rejlek +4 more
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