Results 41 to 50 of about 752,600 (318)

Assessment of Epoxy Functionalized Poly(dimethylsiloxane) Vitrimers Catalyzed with Covalently Attached Amines as Reversible Adhesives

Macromolecular Materials and Engineering, 2022
In this work, vitrimeric elastomers based on functionalized poly(dimethylsiloxane) are realized. By exploiting reactions of epoxide functional groups with carboxylic acids in the presence of a covalently bonded amine catalyst, dynamic networks are formed
Florian Wanghofer, Archim Wolfberger, Gernot Oreski, Sandra Schlögl   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency

Scientific Reports
The popularity of rAAV vectors in gene therapy are placing a burden on current production systems. To improve the accessibility of these life changing treatments, increases in production yields and a reduction in the cost-of-goods are needed.
Brian Ladd, Sofia Tunmats, Torbjörn Gräslund, Olalekan Daramola, Johan Rockberg, Véronique Chotteau   +5 more
doaj   +1 more source

DLMS over Wi-SUN FAN Networks: Performance Evaluation

Applied Sciences
The DLMS (Device Language Message Specification) standard is widely adopted in smart metering systems for utility services, as it defines the mechanisms that enable the standardized and interoperable exchange of data between metering devices. Wi-SUN FAN (
Ananias Ambrosio Quispe, William Lopes de Oliveira, Giancarlo Covolo Heck, Luciana Michelotto Iantorno, Patryk Henrique da Fonseca, Rodrigo Jardim Riella   +5 more
doaj   +1 more source

DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase

Scientific Reports, 2017
The inner uterine lining (endometrium) is a unique tissue going through remarkable changes each menstrual cycle. Endometrium has its characteristic DNA methylation profile, although not much is known about the endometrial methylome changes throughout the
Viktorija Kukushkina, Vijayachitra Modhukur, Marina Suhorutšenko, Maire Peters, Reedik Mägi, Nilufer Rahmioglu, Agne Velthut-Meikas, Signe Altmäe, Francisco J. Esteban, Jaak Vilo, Krina Zondervan, Andres Salumets, Triin Laisk-Podar   +12 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Lessons learned: overcoming common challenges in reconstructing the SARS-CoV-2 genome from short-read sequencing data via CoVpipe2 [version 2; peer review: 2 approved]

F1000Research
Background Accurate genome sequences form the basis for genomic surveillance programs, the added value of which was impressively demonstrated during the COVID-19 pandemic by tracing transmission chains, discovering new viral lineages and mutations, and ...
Martin Hölzer, Stephan Fuchs, René Kmiecinski, Kathrin Trappe, Marie Lataretu, Oliver Drechsel   +5 more
doaj   +1 more source

Dynamics of the Apple Fruit Microbiome after Harvest and Implications for Fruit Quality

Microorganisms, 2021
The contribution of the apple microbiome to the production chain of apple was so far largely unknown. Here, we describe the apple fruit microbiome and influences on its composition by parameters such as storage season, storage duration, storage ...
Yvonne Bösch, Elisabeth Britt, Sarah Perren, Andreas Naef, Jürg E. Frey, Andreas Bühlmann   +5 more
doaj   +1 more source

Midwives' competence : is it affected by working in a rural location? [PDF]

, 2007
Introduction: Rising health care costs and the need to consolidate expertise in tertiary services have led to the centralisation of services. In the UK, the result has been that many rural maternity units have become midwife-led.
Caldow, Jan, Kiger, Alice, Tucker, Janet S., Bryers, Helen, Harris, Fiona Margaret, Harris, Fiona, Farmer, Jane, Ireland, Jillian M, Ireland, Jillian C.M., Hundley, Vanora, Caldow, Jan L., van Teijlingen, Edwin R., Tucker, Janet, van Teijlingen, Edwin   +13 more
core  

Competence Maps for the Information Service Industry

, 2011
The primary aim of this paper is to construct competence maps for the information service industry. Starting with a review of the literature related to the information service industry and the competence in this industry, this study defined a pool of ...
Shih, Ying-wei; Wu, Ya-ling; Wang, Yi-shun; Wang, Yu-min
core   +1 more source