Results 41 to 50 of about 977,003 (310)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
BMC Health Services ResearchBackground Multimorbidity is increasing globally, affecting over one-third of the population. Adults with complex needs often experience physical, mental, and cognitive disorders, leading to increased healthcare utilization, reduced quality of life, and ...
Ulrika Harris +3 more
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Chemistry Teacher International, 2019 Chemistry teaching and learning bears some subject-specific challenges. For example, explanations and considerations of chemical phenomena drawing on the macroscopic, the sub-microscopic and the representational level.
Lembens Anja +4 more
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How Do Deep-Learning Framework Versions Affect the Reproducibility of Neural Network Models?
Machine Learning and Knowledge Extraction, 2022 In the last decade, industry’s demand for deep learning (DL) has increased due to its high performance in complex scenarios. Due to the DL method’s complexity, experts and non-experts rely on blackbox software packages such as Tensorflow and Pytorch. The
Mostafa Shahriari +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Application of the Wave Based Technique for steady-state semi-infinite sound radiation analysis
Computer Assisted Methods in Engineering and Science, 2022 This paper reports on the development of a novel wave based prediction technique for the steady-state sound radiation analysis of three-dimensional semi-infinite problems.
Jan Rejlek +4 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Conceptual determinants of construction project management competence: A Chinese perspective [PDF]
, 2008 In recent years Western project management theories and practices have become increasingly recognized and dispersed in China, particularly in construction-related work.
Chen, Ping +2 more
core +1 more source
Scientific ReportsThe popularity of rAAV vectors in gene therapy are placing a burden on current production systems. To improve the accessibility of these life changing treatments, increases in production yields and a reduction in the cost-of-goods are needed.
Brian Ladd +5 more
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