Results 131 to 140 of about 1,222,459 (387)

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

Advanced Science, EarlyView.
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun, Jiayi Yuan, Divya Jaiswal, Jingxuan Ge, Tianjian Liang, Jiahui Wei, Jinghong Cao, Yulong Li, Xiaojie Chu, Yan Chen, Ying Xue, Wei Li, Tingjun Hou, Zhiwei Feng   +13 more
wiley   +1 more source

Analisis Determinan Akuntabilitas Pengelolaan Keuangan Daerah (Studi Empiris Pada SKPD Pemerintah Kabupaten Kepulauan Talaud) [PDF]

, 2017
. The phenomenon can be observed in the development of the public sector today is the rise of increasingly demands to implement public accountability by public sector organizations (such as: the Central Government and the regions, Government work units ...
Aimbu, L. L. (Lesli), Gamaliel, H. (Hendrik), Saerang, D. P. (David)   +2 more
core  

Dedifferentiation and Transfer in Executive Function and Math Ability Following a Five‐Year Abacus Training in Schoolchildren

Advanced Science, EarlyView.
While cognitive development typically exhibits differentiation, marked by decreasing inter‐domain correlations, this study demonstrates that five‐year abacus training is associated with de‐differentiation of executive function and mathematical ability in school‐aged children.
Tianyong Xu, Xinyang Liu, Hongjian He, Changsong Zhou, Andrea Hildebrandt, Feiyan Chen   +5 more
wiley   +1 more source

KEKUATAN SUMBER DAYA MANUSIA DALAM MEMASARKAN PRODUK DAN DAMPAKNYA PADA KINERJA KARYAWAN ASURANSI JIWA DI PROVINSI KEPULAUAN RIAU

Jurnal Benefita, 2017
The significance of life insurance products is not dependent on technological sophistication and the equipment used, but rather on the service of its Human Resources-based officers, therefore this research wants to see the strength of human resources in ...
Suhardi Suhardi, Syaifullah Syaifullah
doaj   +1 more source

Resource capability for local government in mainstreaming gender into disaster risk reduction: evidence from Indonesia [PDF]

, 2015
Understanding how local government responds to gender vulnerability and gender capacity is important to make cities safer both for women and for men.
Amaratunga, Dilanthi, Yumarni, Tri
core  

ChromInSight: Revealing DNA Double‐Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework

Advanced Science, EarlyView.
DSBs are the most critical genomic lesions. Using the ChromInSight framework, It is revealed that 3D chromatin structure, rather than linear distance, shapes cluster‐scene between hub‐Nodes and DSB loci. The “spatial isolation–damage containment” hypothesis is proposed to illustrate how the genome responds to genomic damage and offer a powerful tool ...
Kang Xu, Zongyuan Yu, Canzhuang Sun, Conglin Gou, Jiangyue Zhu, Jun Wang, Xiaochen Bo, Guoxian Yu, Hao Li, Hebing Chen   +9 more
wiley   +1 more source

MIEJSCE KAPITAŁU LUDZKIEGO W ORGANIZACJI

Nowoczesne Systemy Zarządzania, 2017
In the presented study principles of conducting the personnel policy were described (personnel) which the entirety of forms and methods of the work of the superior was regarded with the subordinate, as at using various forces and funds.
Janusz WIŚNIEWSKI
doaj   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan, Hongyi Chen, Haolin Song, Chufeng Li, Yu Wang, Zhenhao Zhao, Qin Guo, Xuwen Li, Mingxuan Liu, Tao Sun, Chen Jiang   +10 more
wiley   +1 more source