Results 221 to 230 of about 23,722,999 (291)

Clinical competency: a gap in language access training for underserved populations. [PDF]

Med Educ Online
Bell E.
europepmc   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Evidence-Based Nursing Management of Semi-Implantable Intrathecal Drug Delivery Systems for Refractory Cancer Pain: Protocol Development and Clinical Evaluation. [PDF]

Nurs Health Sci
Pan XL, Song XM, Wang XX, Ni Y, Zhang Y, Fan L.   +5 more
europepmc   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

VISIONARA - developing a concept for decentralized competency-based learning in primary health care and its proposed evaluation. [PDF]

GMS J Med Educ
Lübbert J, Schüle D, Wachter C, Kurczyk S, Altiner A, Loukanova S, Leutgeb R.   +6 more
europepmc   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Effect of AI-driven simulation integrated with virtual case-based training on diagnostic and therapeutic reasoning homogenization among junior ophthalmologists: a prospective cohort study. [PDF]

Front Med (Lausanne)
Wu Z, Li L.
europepmc   +1 more source

Academic-practice partnerships in public health workforce development in China: a comparative analysis of 12 purposively selected cases. [PDF]

Front Public Health
Li W, Ren Y, Fan Z, Zhu L, Ma G.
europepmc   +1 more source

Augmented Reality-Based Training for a Rapid Blood Transfusion Device Among Emergency Nurses: Randomized Controlled Trial. [PDF]

JMIR Med Educ
Jang W, Chai W, Kim Y, Moon Y, Yoo S, Na SG, Shin S, Son MH.   +7 more
europepmc   +1 more source