Results 31 to 40 of about 18,107 (260)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Geriatric Medicine Fellowship OSCE Facilitator's Manual

MedEdPORTAL, 2009
Introduction In attempt to reinforce skills that are necessary and relevant to the practice of geriatric medicine, we designed this 22-station objective structured clinical examination (OSCE) for first-year geriatric medicine fellows.
Anita Bagri, Jorge Ruiz, Enrique Aguilar, Evan Cherniack, Adam Golden, Neldes Marranzini, Marcos Milanez, Juan Palacios, Osvaldo Rodriguez, Renuka Tunuguntla, Khin Zaw   +10 more
doaj   +1 more source

Current Competencies of Game Facilitators and Their Potential Optimization in Higher Education: Multimethod Study

JMIR Serious Games, 2021
BackgroundSerious games can be a powerful learning tool in higher education. However, the literature indicates that the learning outcome in a serious game depends on the facilitators’ competencies.
Baalsrud Hauge, Jannicke, Söbke, Heinrich, Bröker, Thomas, Lim, Theodore, Luccini, Angelo Marco, Kornevs, Maksims, Meijer, Sebastiaan   +6 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Research on the effect of professional competency of college physical education teachers on students’ motivation for physical education learning

Frontiers in Psychology
IntroductionThis study, based on self-determination theory, constructs a multilevel model to examine the impact of the professional competency of college physical education teachers (PCCPET) on students’ motivation for physical education learning (SMPEL).
Wanhong Luo, Xu Sun, Zongkai Zhou, Zuguo Tian, Zichao Chen   +4 more
doaj   +1 more source

Using AI to Evaluate a Competency-Based Online Writing Course in Nursing

Online Learning, 2023
Nursing education is transitioning from traditional teaching to competency-based education. Additionally, more nursing courses and programs are now offered online.
Rebecca Red Wolf, Andrew Wolf
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Formación inicial de maestros en la competencia promoción de la valoración positiva de la matemática: un estudio de casos Initial teacher training in the promotion of positive assessment of mathematics competition: a case study

Transformación, 2018
The paper describes the results of a case study aimed at developing the competence to promoting positive assessment of mathematics in primary school teachers under training.
Isidro Báez Suero, María de los Ángeles Legañoa Ferrá, Dr. C. Jorge García Batán   +2 more
doaj  

Exploring Project-Based Learning within an Independent Curriculum: A Qualitative Inquiry into Technical Drawing Competence in Vocational Automotive Education

Journal of Transdisiplinary Studies in Education
Background: Vocational education is undergoing curriculum reform that emphasizes learner autonomy and competency-based learning, yet evidence on its implementation in technical drawing instruction remains limited.
Ridwan Ridwan, Riyan Saputra, Mardiyah Mardiyah   +2 more
doaj   +1 more source