Results 121 to 130 of about 32,553,819 (299)

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The State of Mastery Learning in Pediatric Graduate Medical Education: A Scoping Review

Advances in Medical Education and Practice
Michaela Mills-Rudy,1 Megan Thorvilson,1 Cynthia Chelf,2 Stephanie Mavis3 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; 2Mayo Clinic College of Medicine and Science, Rochester, MN, USA; 3Department of Pediatric and ...
Mills-Rudy M, Thorvilson M, Chelf C, Mavis S   +3 more
doaj  

Rheumatology training and awareness among undergraduates in Indian medical schools: a multicenter observational study

BMC Medical Education
Background Rheumatic and musculoskeletal diseases, which are prevalent in nearly 25–30% of the Indian population, pose a significant burden on public health. However, the field is often overlooked in undergraduate medical curricula, leading to a shortage
Deepti Agarwal, Kavita Krishna, Srilakshmi Sathiyaseelan, Sandeep Kansurkar   +3 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Matrizes para a Aquisição de Competências no Ensino de Urgências Clínicas / Ensino de Urgências Orientado por Competências

Revista Brasileira de Educação Médica
RESUMO A Faculdade de Ciências Médicas e da Saúde (FCMS) da PUC-SP, campus Sorocaba, inseriu o aluno do internato em uma Unidade de Pronto Atendimento no estágio de urgências clínicas com os objetivos de melhorar o processo de ensino-aprendizagem em ...
Maria Helena Senger, Maria Celeste Gonçalves Campos   +1 more
doaj   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Development of an Outcome-Based Medical Curriculum: A Case Report from The Catholic University of Korea School of Medicine [PDF]

, 2013
The recent medical education paradigm shift from teacher-centered to student-centered education, has led to a concentration on students’ performance and competency.
연세대학교 의과대학
core  

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Trust as a Scaffold for Competency-Based Medical Education [PDF]

Journal of General Internal Medicine, 2019
Eric, Young, D Michael, Elnicki
openaire   +2 more sources