Results 181 to 190 of about 1,232,754 (357)

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

open access: yesAdvanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang   +8 more
wiley   +1 more source

Thermally Reconstructed Ru/La‐Co3O4 Nanosheets with Super Thermal Stability for Catalytic Combustion of Light Hydrocarbons: Induced Surface LaRuO3 Active Phase

open access: yesAdvanced Science, EarlyView.
The high‐temperature induced the exsolution of La from La‐Co3O4 lattice and facilitated the in situ formation of highly active LaRuO3 perovskite through a solid‐phase reaction with surface RuOx. This process significantly enhanced the thermal and hydrothermal stability of Ru/La‐Co3O4 for light hydrocarbons (LHs) oxidation, providing an innovative ...
Biao Gao   +11 more
wiley   +1 more source

Developing and validating a scale of empowerment in using artificial intelligence for problem-solving for senior secondary and university students

open access: yesComputers and Education: Artificial Intelligence
Empowerment enables students to be psychologically and affectively ready to leverage the benefits of artificial intelligence (AI). However, a theory-driven scale to extend empowerment into the use of AI for problem-solving is lacking.
Siu Cheung Kong   +2 more
doaj  

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

open access: yesAdvanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun   +23 more
wiley   +1 more source

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

open access: yesAdvanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi   +9 more
wiley   +1 more source

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