Results 181 to 190 of about 1,232,754 (357)
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang+8 more
wiley +1 more source
The high‐temperature induced the exsolution of La from La‐Co3O4 lattice and facilitated the in situ formation of highly active LaRuO3 perovskite through a solid‐phase reaction with surface RuOx. This process significantly enhanced the thermal and hydrothermal stability of Ru/La‐Co3O4 for light hydrocarbons (LHs) oxidation, providing an innovative ...
Biao Gao+11 more
wiley +1 more source
Empowerment enables students to be psychologically and affectively ready to leverage the benefits of artificial intelligence (AI). However, a theory-driven scale to extend empowerment into the use of AI for problem-solving is lacking.
Siu Cheung Kong+2 more
doaj
Repair of U.V. damages in Bacillus subtilis cultures competent for transformation: difference between competent and non-competent fractions [PDF]
Giuseppe Sgroi+2 more
openalex +1 more source
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun+23 more
wiley +1 more source
Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi+9 more
wiley +1 more source