Results 91 to 100 of about 767,407 (301)

Mesoscopic Interactions and Species Coexistence in Evolutionary Game Dynamics of Cyclic Competitions [PDF]

, 2014
Date of Acceptance: 27/11/2014Peer reviewedPublisher ...
Cheng, Hongyan, Do, Younghae, Huang, Zi-Gang, Lai, Ying-Cheng, Park, Junpyo, Yao, Nan   +5 more
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The Animal Sexes as Historical Explanatory Kinds [PDF]

, 2020
Though biologists identify individuals as ‘male’ or ‘female’ across a broad range of animal species, the particular traits exhibited by males and females can vary tremendously.
Franklin-Hall, Laura
core   +1 more source

Synthetic biology and biosecurity: challenging the ‘myths’

Frontiers in Public Health, 2014
Synthetic biology, a field that aims to ‘make biology easier to engineer’, is routinely described as leading to an increase in the ‘dual use’ threat, i.e.
Catherine eJefferson, Filippa eLentzos, Claire eMarris   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Exploring MYC relevance to cancer biology from the perspective of cell competition

Seminars in Cancer Biology, 2020
Cancer has long been regarded and treated as a foreign body appearing by mistake inside a living organism. However, now we know that cancer cells communicate with neighbours, thereby creating modified environments able to support their unusual need for nutrients and space.
Simona Paglia, Manuela Sollazzo, Simone Di Giacomo, Slivia Strocchi, Daniela Grifoni   +4 more
openaire   +3 more sources

Receptor uptake arrays for vitamin B12, siderophores and glycans shape bacterial communities

, 2017
Molecular variants of vitamin B12, siderophores and glycans occur. To take up variant forms, bacteria may express an array of receptors. The gut microbe Bacteroides thetaiotaomicron has three different receptors to take up variants of vitamin B12 and 88 ...
Frank, Steven A.
core   +1 more source

Genetic differentiation of prey predator interaction model along with an Holling type-II functional response

Partial Differential Equations in Applied Mathematics
Prey–predator models play a vital role in mathematical biology. The competition that evolves between them is addressed in a broad scenario. According to genetics theory, various specie’s genotypes yield different outcomes in competition.
G. Santhosh Kumar, C. Gunasundari, Salah Mahmoud Boulaaras, M. Aakash, N.B. Sharmila   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Synthetic biology in Mexico: Brief history, current landscape, and perspectives towards a bio‐based economy

Engineering Biology
Synthetic biology (SynBio) makes biology easier by leveraging engineering principles and other disciplines to design and construct biological systems with novel or enhanced functions. SynBio has led to the development of more sustainable biotechnological
Uriel E. Barboza‐Pérez, Ma de L. Pérez‐Zavala, José E. Barboza‐Corona   +2 more
doaj   +1 more source