Results 41 to 50 of about 766,564 (291)

Divergent Biosynthesis of C-Nucleoside Minimycin and Indigoidine in Bacteria

iScience, 2019
Summary: Minimycin (MIN) is a C-nucleoside antibiotic structurally related to pseudouridine, and indigoidine is a naturally occurring blue pigment produced by diverse bacteria.
Liyuan Kong, Gudan Xu, Xiaoqin Liu, Jingwen Wang, Zenglin Tang, You-Sheng Cai, Kun Shen, Weixin Tao, Yu Zheng, Zixin Deng, Neil P.J. Price, Wenqing Chen   +11 more
doaj   +1 more source

Burden Imposed by Heterologous Protein Production in Two Major Industrial Yeast Cell Factories: Identifying Sources and Mitigation Strategies

Frontiers in Fungal Biology, 2022
Production of heterologous proteins, especially biopharmaceuticals and industrial enzymes, in living cell factories consumes cellular resources. Such resources are reallocated from normal cellular processes toward production of the heterologous protein ...
Louise La Barbera Kastberg, Ryan Ard, Michael Krogh Jensen, Christopher T. Workman   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

New Conditional Symmetries and Exact Solutions of the Diffusive Two-Component Lotka–Volterra System

Mathematics, 2021
The diffusive Lotka–Volterra system arising in an enormous number of mathematical models in biology, physics, ecology, chemistry and society is under study. New Q-conditional (nonclassical) symmetries are derived and applied to search for exact solutions
Roman Cherniha, Vasyl’ Davydovych
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites [PDF]

, 2014
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of ...
A Gelman, AF Read, AJ O'Donnell, Andrew F. Read, AR Wargo, AR Wargo, AS Bell, BF Kochin, CJE Metcalf, D Cromer, DJC MacKay, DT Haydon, EM Pantelouris, G Snounou, GN Jakeman, H Haario, I Singer, IM Hastings, Jayanthi Santhanam, JC de Roode, JC de Roode, JC de Roode, JW Field, JW Field, KP Day, L Molineaux, L Raberg, Lars Råberg, LH Taylor, LH Taylor, LM van Putten, M Dyer, M Girolami, M Good, M Mackey, MC Bruce, Mercedes Pascual, MJ Mackinnon, MJ Mackinnon, MM Stevenson, MR Miller, N Friel, N Mideo, N Mideo, Nicholas Jon Savill, NJ Savill, PG McQueen, PH Abbrecht, R Antia, RO McAlister, TL Richie   +50 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Kin Selection in the RNA World

Life, 2017
Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions.
Samuel R. Levin, Stuart A. West
doaj   +1 more source

Incidence and post-pollination mechanisms of nonrandom mating in Arabidopsis thaliana [PDF]

, 2009
Compatible pollinations from many differenttaxa display nonrandom mating. Here we describe a systemfor examining questions of nonrandom mating in Arabidopsisthaliana.
Carlson, Ann L, Swanson, Rob, Telligman, Megan   +2 more
core   +3 more sources

Advancing computational biology and bioinformatics research through open innovation competitions

PLOS ONE, 2019
SummaryOpen data science and algorithm development competitions offer a unique avenue for rapid discovery of better computational strategies. We highlight three examples in computational biology and bioinformatics research where the use of competitions has yielded significant performance gains over established algorithms.
Andrea Blasco, Michael G. Endres, Rinat A. Sergeev, Anup Jonchhe, N. J. Maximilian Macaluso, Rajiv Narayan, Ted Natoli, Jin H. Paik, Bryan Briney, Chunlei Wu, Andrew I. Su, Aravind Subramanian, Karim R. Lakhani   +12 more
openaire   +5 more sources