Results 61 to 70 of about 766,564 (291)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
LAG3’s Enigmatic Mechanism of Action
Frontiers in Immunology, 2021 LAG3 is an important immune checkpoint with relevance in cancer, infectious disease and autoimmunity. However, despite LAG3’s role in immune exhaustion and the great potential of LAG3 inhibition as treatment, much remains unknown about its biology ...
Colin G. Graydon +5 more
doaj +1 more source
, 2011 Laws of nature take center stage in philosophy of science. Laws are usually believed to stand in a tight conceptual relation to many important key concepts such as causation, explanation, confirmation, determinism, counterfactuals etc.
Hüttemann, Andreas +2 more
core +1 more source
Relationships Between Habitat and Snag Characteristics and the Reproductive Success of the Brown-headed Nuthatch (Sitta pusilla) in Eastern Texas. [PDF]
, 2004 Habitat use and reproductive success of the Brown-headed Nuthatch (Sitta pusilla Latham) were studied in East Texas during the 2001-2002 breeding seasons. We compared nest cavity selection at used and randomly selected non-used areas.
Burt, Brent +3 more
core +2 more sources
Scinapse 2019-2020 Undergraduate Science Case Competition: Augmented Biology
Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal, 2020 The Scinapse Undergraduate Science Case Competition (USCC) provides an opportunity for undergraduate students to experience the development of a novel research proposal. A case is presented to all participants and, using in-depth literature search (publications, reports, studies and published writings), students connect and pinpoint key ...
Clarissa Ngo +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Biosfer, 2021 Scientific reasoning and problem-solving have become primary interests in 21st-century education. These skills have an essential role in preparing students to face global competition.
Maisuna Kundariati +5 more
doaj +1 more source
The Food Web of Potter Cove (Antarctica): complexity, structure and function [PDF]
, 2018 Knowledge of the food web structure and complexity are central to better understand ecosystem functioning. A food-web approach includes both species and energy flows among them, providing a natural framework for characterizing species’ ecological roles ...
Barrera Oro, Esteban +14 more
core +2 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A two-strain ecoepidemic competition model
, 2014 In this paper we consider a competition system in which two diseases spread by contact. We characterize the system behavior, establishing that only some configurations are possible.
Cavoretto, Roberto +3 more
core +1 more source