Results 61 to 70 of about 1,029,116 (295)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The dynamics of competitive learning: the role of updates and memory
, 2012 We examine the effects of memory and different updating paradigms in a game-theoretic model of competitive learning, where agents are influenced in their choice of strategy by both the choices made by, and the consequent success rates of, their immediate
Bhat, Ajaz Ahmad, Mehta, Anita
core +1 more source
Dynamic Conic Hedging for Competitiveness [PDF]
SSRN Electronic Journal, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Madan, DB, Pistorius, M, Schoutens, W
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Vector interaction model of factors of retailers` competitiveness [PDF]
Marketing i Menedžment Innovacij, 2013 The aim of the article. The aim of the article is to develop scientific and methodical approach to the modeling and analysis of complex elements, settings, and the phase trajectories of competition in the market.
T.O. Zagornaya
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Environmental Research Letters, 2020 Plant succession is regulated by a combination of abiotic and biotic factors. However, previous studies of biotic drivers have focused overwhelmingly on direct pairwise species interactions, ignoring the likely prevalent higher-order interactions (HOIs ...
Junli Xiao +5 more
doaj +1 more source
Boom-bust population dynamics increase diversity in evolving competitive communities
Communications Biology, 2021 Michael Doebeli et al. introduce a discrete-time competition model with multi-dimensional evolving phenotypes to explore the effect of boom-bust population dynamics on the evolution of diversity.
Michael Doebeli +2 more
doaj +1 more source
Competitive dynamics of web sites [PDF]
Journal of Economic Dynamics and Control, 2000 We present a dynamical model of web site growth in order to explore the effects of competition among web sites and to determine how they affect the nature of markets. We show that under general conditions, as the competition between sites increases, the model exhibits a sudden transition from a regime in which many sites thrive simultaneously, to a ...
Maurer, Sebastian M. +1 more
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Competitive Dynamics of Market Entry: Scale and Survival [PDF]
Management and Economics Review, 2017 Market entry is the essence of strategy and is largely viewed as a dichotomous event: entry or no entry. What has not been acknowledged is the uniqueness of each market entry.
John W. UPSON +2 more
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