Results 1 to 10 of about 844,522 (297)
Frontiers in Immunology, 2021 C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP.
Ola Kamala +15 more
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Frontiers in Immunology, 2021 Membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), atypical haemolytic uraemic syndrome (aHUS) and age-related macular degeneration (AMD) have all been strongly linked with dysfunction of the alternative pathway (AP) of complement.
Edwin K. S. Wong +23 more
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Virus-Encoded Complement Regulators: Current Status
Viruses, 2021 Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha +4 more
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Complement in trauma—Traumatised complement? [PDF]
British Journal of Pharmacology, 2020 Physical trauma represents a major global burden. The trauma‐induced response, including activation of the innate immune system, strives for regeneration but can also lead to post‐traumatic complications. The complement cascade is rapidly activated by damaged tissue, hypoxia, exogenous proteases and others.
Markus S. Huber‐Lang +4 more
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BMJ Open, 2022 Introduction Atypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening disease caused by excessive activation of part of the immune system called complement. Eculizumab is an effective treatment, controlling aHUS in 90% of patients.
Andrew Bryant +14 more
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Complement System: Promoter or Suppressor of Cancer Progression?
Antibodies, 2020 Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain
Margot Revel +4 more
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Genome Medicine, 2020 Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for ...
Florent Petitprez +12 more
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Frontiers in Immunology, 2022 Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic variants in complement factor H (CFH; FH) and factor I (CFI; FI) are associated
Thomas M. Hallam +26 more
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SUBSTITUTING COMPLEMENTS [PDF]
Journal of Competition Law & Economics, 2006 The presence of multiple sellers in the provision of (nonsubstitutable) complementary goods leads to outcomes that are worse than those generated by a monopoly (with a vertically integrated production of complements), a problem known in the economic literature as complementary oligopoly and recently popularized in the legal literature as the tragedy of
PARISI, FRANCESCO, G. Dari Mattiacci
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Acta Arithmetica, 2023 In this paper we prove that if $A$ and $B$ are infinite subsets of positive integers such that every positive integer $n$ can be written as $n=ab$, $a\in A$, $b\in B$, then $\displaystyle \lim_{x\to \infty}\frac{A(x)B(x)}{x}=\infty $. We also prove many other results about sets like this.
Anett Kocsis +3 more
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