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Complement system part I - molecular mechanisms of activation and regulation
Frontiers in Immunology, 2015 Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Nicolas eMerle +3 more
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Complement system part II: role in immunity
Frontiers in Immunology, 2015 The complement system has been considered for a long time as a simple lytic system, aimed to kill bacteria infecting the host organism. Nowadays this vision has changed and it is well accepted that complement is a complex innate immune surveillance ...
Nicolas S. Merle +4 more
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Frontiers in Immunology, 2021 C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP.
Ola Kamala +15 more
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Frontiers in Immunology, 2021 Membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), atypical haemolytic uraemic syndrome (aHUS) and age-related macular degeneration (AMD) have all been strongly linked with dysfunction of the alternative pathway (AP) of complement.
Edwin K. S. Wong +23 more
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Complosome — the intracellular complement system
Nature Reviews Nephrology, 2023 The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which ...
E. West, C. Kemper
semanticscholar +1 more source
Virus-Encoded Complement Regulators: Current Status
Viruses, 2021 Viruses require a host for replication and survival and hence are subjected to host immunological pressures. The complement system, a crucial first response of the host immune system, is effective in targeting viruses and virus-infected cells, and ...
Anwesha Sinha +4 more
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BMJ Open, 2022 Introduction Atypical haemolytic uraemic syndrome (aHUS) is a rare, life-threatening disease caused by excessive activation of part of the immune system called complement. Eculizumab is an effective treatment, controlling aHUS in 90% of patients.
Andrew Bryant +14 more
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Complement System: Promoter or Suppressor of Cancer Progression?
Antibodies, 2020 Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain
Margot Revel +4 more
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Frontiers in Immunology, 2022 Age-related macular degeneration (AMD) is linked to 2 main disparate genetic pathways: a chromosome 10 risk locus and the alternative pathway (AP) of complement. Rare genetic variants in complement factor H (CFH; FH) and factor I (CFI; FI) are associated
Thomas M. Hallam +26 more
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Genome Medicine, 2020 Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for ...
Florent Petitprez +12 more
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